Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0701 | 0.9782 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.2367 | 0.2176 |
Loa Loa (eye worm) | hypothetical protein | 0.0467 | 0.6327 | 0.6355 |
Echinococcus granulosus | Desert hedgehog protein | 0.0578 | 0.7972 | 0.7972 |
Onchocerca volvulus | 0.0467 | 0.6327 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0388 | 0.5166 | 0.5129 |
Schistosoma mansoni | hypothetical protein | 0.0421 | 0.5655 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0396 | 0.5284 | 0.5284 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0 | 0.5 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0396 | 0.5284 | 0.8352 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0388 | 0.5166 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0388 | 0.5166 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0467 | 0.6327 | 0.6355 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0388 | 0.5166 | 0.8164 |
Brugia malayi | hypothetical protein | 0.0467 | 0.6327 | 1 |
Schistosoma mansoni | lozenge | 0.0059 | 0.0304 | 0.0538 |
Echinococcus multilocularis | Protein lozenge | 0.0059 | 0.0304 | 0.0304 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0396 | 0.5284 | 0.9345 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0396 | 0.5284 | 0.5284 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1758 | 0.1534 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0388 | 0.5166 | 1 |
Echinococcus multilocularis | smoothened | 0.0716 | 1 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0396 | 0.5284 | 0.5255 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1758 | 0.1534 |
Echinococcus multilocularis | hedgehog | 0.0578 | 0.7972 | 0.7972 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0 | 0.5 |
Brugia malayi | Hint module family protein | 0.0157 | 0.1758 | 0.2778 |
Brugia malayi | Hint module family protein | 0.0157 | 0.1758 | 0.2778 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.21 uM | Inhibition of cell growth in culture against,wild type P388 murine leukemia | ChEMBL. | 2033580 |
IC50 (functional) | = 1.21 uM | Inhibition of cell growth in culture against,wild type P388 murine leukemia | ChEMBL. | 2033580 |
IC50 (functional) | = 2.85 uM | Inhibition of cell growth in culture against,Chinese hamster ovary derived cell line, AA8 | ChEMBL. | 2033580 |
IC50 (functional) | = 3.8 uM | Inhibition of cell growth in culture against,wild type P388 murine leukemia | ChEMBL. | 2033580 |
IC50 (functional) | = 3.8 uM | Inhibition of cell growth in culture against,wild type P388 murine leukemia | ChEMBL. | 2033580 |
IC50 (functional) | = 6.9 uM | Compound was evaluated for the inhibition of cell growth in culture against,Chinese hamster ovary derived cell line, AA8 | ChEMBL. | 2033580 |
Increase (functional) | NA 0 % | Evaluation in vivo against P338 cell line for percentage increase in lifespan of drug-treated tumor-bearing animals at 100 mg/kg dose.(ILS); NA=Compound inactive at nontoxic doses | ChEMBL. | 2033580 |
K obs (ADMET) | = 0.26 | Pseudo first-order rate constant of the compound was determined | ChEMBL. | 2033580 |
Log K (ADMET) | = 6.61 M-1 | Spectrophotometry of the compound was determined for binding to calf thymus DNA in 0.01 M HEPES buffer (pH 7.0) at 25 degree C | ChEMBL. | 2033580 |
Ratio (functional) | = 3.6 | Hypersensitivity factor value is IC50 of (AA8) to that of UV4 where UV4 is a mutant AA8 line lacking the ability to perform incision repair | ChEMBL. | 2033580 |
Ratio (functional) | = 6.4 | Hypersensitivity factor value is IC50 of (AA8) to that of UV4 where UV4 is a mutant AA8 line lacking the ability to perform incision repair | ChEMBL. | 2033580 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 2033580 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.