Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | serine threonine-protein kinase, putative | 0.011 | 0.1502 | 0.2721 |
Loa Loa (eye worm) | glutaminase | 0.0286 | 0.5315 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.0113 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.1403 | 0.1336 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.2714 | 0.5107 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0111 | 0.1525 | 0.1989 |
Brugia malayi | glutaminase DH11.1 | 0.0286 | 0.5315 | 0.5315 |
Schistosoma mansoni | ornithine--oxo-acid transaminase | 0.0045 | 0.0077 | 0.0144 |
Onchocerca volvulus | 0.0058 | 0.0359 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | acetylornithine transaminase protein | 0.0045 | 0.0077 | 0.5 |
Chlamydia trachomatis | glutamate-1-semialdehyde-2,1-aminomutase | 0.0045 | 0.0077 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.1403 | 0.1336 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.0113 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.007 | 0.0631 | 0.1188 |
Mycobacterium ulcerans | glutaminase | 0.0286 | 0.5315 | 0.5278 |
Mycobacterium tuberculosis | Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) | 0.0502 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0217 | 0.3808 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0111 | 0.1517 | 0.2854 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.1403 | 0.1336 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.0113 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.0113 | 0.0147 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0046 | 0.0113 | 0.0036 |
Echinococcus granulosus | geminin | 0.0166 | 0.2714 | 0.3539 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0047 | 0.0134 | 0.0175 |
Echinococcus multilocularis | tumor protein p63 | 0.0395 | 0.7668 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.1403 | 0.1336 |
Brugia malayi | jmjC domain containing protein | 0.0111 | 0.1525 | 0.1525 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0118 | 0.1659 | 0.1594 |
Schistosoma mansoni | jumonji domain containing protein | 0.0089 | 0.1028 | 0.1934 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | glutaminase 2 | 0.0286 | 0.5315 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.0113 | 1 |
Echinococcus granulosus | Aminotransferase class III | 0.0045 | 0.0077 | 0.01 |
Mycobacterium ulcerans | L-lysine aminotransferase | 0.0502 | 1 | 1 |
Brugia malayi | glutathione reductase | 0.0046 | 0.0113 | 0.0113 |
Echinococcus multilocularis | Aminotransferase class III | 0.0045 | 0.0077 | 0.01 |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.0217 | 0.3808 | 0.4966 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.0113 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0058 | 0.0359 | 0.0676 |
Loa Loa (eye worm) | IRE protein kinase | 0.0217 | 0.3808 | 0.7165 |
Trichomonas vaginalis | conserved hypothetical protein | 0.011 | 0.1502 | 0.2721 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.1403 | 0.1336 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0106 | 0.1403 | 0.838 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.0113 | 1 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0045 | 0.0077 | 0.01 |
Echinococcus granulosus | ornithine aminotransferase | 0.0045 | 0.0077 | 0.01 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.0113 | 0.0147 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.2714 | 0.5107 |
Brugia malayi | Ribonuclease 2-5A family protein | 0.0217 | 0.3808 | 0.3808 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0111 | 0.1525 | 0.1989 |
Echinococcus granulosus | tumor protein p63 | 0.0395 | 0.7668 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0118 | 0.1659 | 0.1594 |
Echinococcus granulosus | jumonji domain containing protein | 0.0047 | 0.0134 | 0.0175 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0359 | 0.0676 |
Trichomonas vaginalis | glutaminase, putative | 0.0286 | 0.5315 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.0113 | 0.0212 |
Entamoeba histolytica | protein kinase, putative | 0.0217 | 0.3808 | 0.5 |
Leishmania major | trypanothione reductase | 0.0046 | 0.0113 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.1403 | 0.1336 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0118 | 0.1659 | 1 |
Echinococcus multilocularis | geminin | 0.0166 | 0.2714 | 0.3539 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.0113 | 0.0212 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0118 | 0.1659 | 0.1594 |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.0217 | 0.3808 | 0.4966 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.0113 | 0.5 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0045 | 0.0077 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0372 | 0.0701 |
Schistosoma mansoni | glutaminase | 0.0286 | 0.5315 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.