Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1015 | 0.2372 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0115 | 0.3079 | 1 |
Onchocerca volvulus | 0.0115 | 0.3079 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0115 | 0.3079 | 1 |
Plasmodium falciparum | conserved protein, unknown function | 0.0115 | 0.3079 | 0.5 |
Brugia malayi | endochitinase | 0.0081 | 0.1768 | 0.5741 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0115 | 0.3079 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0532 | 0.0582 |
Brugia malayi | endochitinase | 0.0073 | 0.1429 | 0.4642 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0115 | 0.3079 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.4007 | 0.3007 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0374 | 0.1215 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0374 | 0.1215 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0374 | 0.1215 |
Brugia malayi | Endochitinase | 0.0081 | 0.1768 | 0.5741 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0073 | 0.1429 | 0.39 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0374 | 0.1215 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0071 | 0.1354 | 0.3623 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0295 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.0571 | 0.0358 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.3079 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0115 | 0.3079 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0532 | 0.1727 |
Onchocerca volvulus | Putative endochitinase | 0.0081 | 0.1768 | 0.2052 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0295 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.4007 | 0.3871 |
Mycobacterium ulcerans | hypothetical protein | 0.0155 | 0.4615 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0115 | 0.3079 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0374 | 0.1215 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0155 | 0.4615 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0374 | 0.1215 |
Loa Loa (eye worm) | chitinase I | 0.0073 | 0.1429 | 0.39 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0532 | 0.1727 |
Onchocerca volvulus | Putative endochitinase | 0.0081 | 0.1768 | 0.2052 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0374 | 0.1215 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0374 | 0.1215 |
Entamoeba histolytica | chitinase, putative | 0.0073 | 0.1429 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.014 | 0.4007 | 0.3871 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.3079 | 1 |
Onchocerca volvulus | 0.0115 | 0.3079 | 1 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0295 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0532 | 0.0582 |
Onchocerca volvulus | Putative endochitinase | 0.0081 | 0.1768 | 0.2052 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.515 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.499 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.358 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.241 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.