Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.4007 | 0.3007 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0295 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0374 | 0.1215 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0115 | 0.3079 | 1 |
Plasmodium falciparum | conserved protein, unknown function | 0.0115 | 0.3079 | 0.5 |
Onchocerca volvulus | Putative endochitinase | 0.0081 | 0.1768 | 0.2052 |
Brugia malayi | Endochitinase | 0.0081 | 0.1768 | 0.5741 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0374 | 0.1215 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0374 | 0.1215 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.014 | 0.4007 | 0.3871 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0532 | 0.1727 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0374 | 0.1215 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1015 | 0.2372 |
Onchocerca volvulus | 0.0115 | 0.3079 | 1 | |
Loa Loa (eye worm) | microfilarial chitinase | 0.0071 | 0.1354 | 0.3623 |
Entamoeba histolytica | chitinase, putative | 0.0073 | 0.1429 | 1 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0115 | 0.3079 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0374 | 0.1215 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0532 | 0.0582 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0374 | 0.1215 |
Brugia malayi | endochitinase | 0.0081 | 0.1768 | 0.5741 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.0571 | 0.0358 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0115 | 0.3079 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0532 | 0.1727 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0532 | 0.0582 |
Onchocerca volvulus | Putative endochitinase | 0.0081 | 0.1768 | 0.2052 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0155 | 0.4615 | 1 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0073 | 0.1429 | 0.39 |
Brugia malayi | endochitinase | 0.0073 | 0.1429 | 0.4642 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.3079 | 1 |
Loa Loa (eye worm) | chitinase I | 0.0073 | 0.1429 | 0.39 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0374 | 0.1215 |
Mycobacterium ulcerans | hypothetical protein | 0.0155 | 0.4615 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0374 | 0.1215 |
Onchocerca volvulus | Putative endochitinase | 0.0081 | 0.1768 | 0.2052 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0295 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0115 | 0.3079 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0115 | 0.3079 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.3079 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0115 | 0.3079 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.4007 | 0.3871 |
Onchocerca volvulus | 0.0115 | 0.3079 | 1 | |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0295 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.515 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.499 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.358 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.241 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.