Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | NA 0 mg kg-1 | Compound was tested for the neuroleptic activity as measured by it's antagonism of d-amphetamine induced lethality in grouped mice(GAL) when administered perorally; Inactive at 20 mg/kg | ChEMBL. | 6110781 |
MDD50 (functional) | 0 mg kg-1 | Dose of the compound causing 50% reduction of motor activity in rats was measured when administered perorally; Not tested | ChEMBL. | 6110781 |
MED (functional) | = 1.6 mg kg-1 | Minimum effective dose of the compound causing antagonism of tetrabenazine induced depression in mice was determined when administered perorally | ChEMBL. | 6110781 |
MED (functional) | = 1.6 mg kg-1 | Minimum effective dose of the compound causing antagonism of tetrabenazine induced depression in mice was determined when administered perorally | ChEMBL. | 6110781 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.