Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0859 | 1 | 1 | |
Toxoplasma gondii | aminopeptidase n, putative | 0.0089 | 0 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0253 | 0.2129 | 0.2129 |
Loa Loa (eye worm) | hypothetical protein | 0.077 | 0.8846 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0606 | 0.6717 | 0.7593 |
Loa Loa (eye worm) | aminopeptidase N | 0.0253 | 0.2129 | 0.2407 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0239 | 0.195 | 0.9157 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0253 | 0.2129 | 1 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0089 | 0 | 0.5 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0253 | 0.2129 | 0.2129 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0253 | 0.2129 | 0.2129 |
Schistosoma mansoni | family M1 non-peptidase homologue (M01 family) | 0.0164 | 0.0975 | 0.4578 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0253 | 0.2129 | 0.2129 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1502 | 0.7053 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0253 | 0.2129 | 1 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0253 | 0.2129 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.195 | 0.2204 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0253 | 0.2129 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.1502 | 0.1502 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1502 | 0.7053 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.195 | 0.2204 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0695 | 0.7871 | 0.8898 |
Toxoplasma gondii | aminopeptidase N protein | 0.0089 | 0 | 0.5 |
Brugia malayi | Cation transporter family protein | 0.0239 | 0.195 | 0.195 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0253 | 0.2129 | 0.2129 |
Onchocerca volvulus | 0.0239 | 0.195 | 0.195 | |
Echinococcus multilocularis | aminopeptidase N | 0.0859 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1502 | 0.1502 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0253 | 0.2129 | 1 |
Onchocerca volvulus | 0.0253 | 0.2129 | 0.2129 | |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0253 | 0.2129 | 1 |
Onchocerca volvulus | 0.0239 | 0.195 | 0.195 | |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.0089 | 0 | 0.5 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.0089 | 0 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0239 | 0.195 | 0.9157 |
Echinococcus granulosus | aminopeptidase N | 0.0859 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0253 | 0.2129 | 0.2129 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0253 | 0.2129 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0164 | 0.0975 | 0.4578 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0253 | 0.2129 | 1 |
Onchocerca volvulus | 0.0239 | 0.195 | 0.195 | |
Entamoeba histolytica | aminopeptidase, putative | 0.0253 | 0.2129 | 0.5 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0089 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1724 | 0.1949 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0253 | 0.2129 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0253 | 0.2129 | 1 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0253 | 0.2129 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0253 | 0.2129 | 0.2129 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0164 | 0.0975 | 0.0975 |
Brugia malayi | Peptidase family M1 containing protein | 0.0253 | 0.2129 | 0.2129 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0253 | 0.2129 | 0.2129 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.0975 | 0.1102 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0253 | 0.2129 | 1 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0253 | 0.2129 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.0975 | 0.1102 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0253 | 0.2129 | 0.2129 |
Toxoplasma gondii | aminopeptidase N, putative | 0.0089 | 0 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0253 | 0.2129 | 0.2129 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0253 | 0.2129 | 0.2129 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 14.8 ug ml-1 | Antiamoebic activity against Entamoeba histolytica | ChEMBL. | No reference |
Potency (ADMET) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] | ChEMBL. | No reference |
Potency (ADMET) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Entamoeba histolytica | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.