Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0422 | 0.1064 | 0.0871 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.3723 | 1 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0107 | 0.0212 | 0.0212 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0029 | 0 | 0.5 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0107 | 0.0212 | 0.0212 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0107 | 0.0212 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.077 | 0.057 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.3723 | 1 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0422 | 0.1064 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.1588 | 0.4221 | 0.4096 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.3723 | 1 | 1 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0107 | 0.0212 | 0.5 |
Brugia malayi | hypothetical protein | 0.012 | 0.0247 | 0.0036 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0107 | 0.0212 | 0.5 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0107 | 0.0212 | 1 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.3723 | 1 | 1 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0029 | 0 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0422 | 0.1064 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.3723 | 1 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.0212 | 0.0212 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0422 | 0.1064 | 0.0871 |
Trichomonas vaginalis | conserved hypothetical protein | 0.3723 | 1 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0107 | 0.0212 | 0.0212 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.0212 | 0.0212 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.3723 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.0506 | 0.03 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0749 | 0.1948 | 0.1774 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0107 | 0.0212 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0422 | 0.1064 | 0.0871 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.3723 | 1 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.1588 | 0.4221 | 0.4096 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.3723 | 1 | 1 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0107 | 0.0212 | 0.5 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0749 | 0.1948 | 0.1774 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0107 | 0.0212 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0107 | 0.0212 | 0.5 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.0212 | 0.0212 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.3723 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.2 nM | Compound tested in vitro for inhibition of Angiotensin I converting enzyme in rat | ChEMBL. | 2544729 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.