Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0194 | 0.5321 | 0.2979 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0189 | 0.5124 | 0.5 |
Leishmania major | guanosine monophosphate reductase | 0.0194 | 0.5321 | 0.2979 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0194 | 0.5321 | 1 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0189 | 0.5124 | 0.9548 |
Trypanosoma brucei | GMP reductase | 0.0194 | 0.5321 | 0.2979 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0194 | 0.5321 | 0.2979 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0105 | 0.1688 | 0.1633 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0194 | 0.5321 | 0.5 |
Loa Loa (eye worm) | GMP reductase | 0.0083 | 0.0782 | 0.147 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0194 | 0.5321 | 1 |
Onchocerca volvulus | Putative GMP reductase | 0.0083 | 0.0782 | 0.5 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0194 | 0.5321 | 1 |
Brugia malayi | GMP reductase | 0.0083 | 0.0782 | 0.147 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0083 | 0.0782 | 0.147 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0194 | 0.5321 | 0.2979 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0307 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0194 | 0.5321 | 0.2979 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0194 | 0.5321 | 1 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0189 | 0.5124 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0307 | 1 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0083 | 0.0782 | 0.147 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0194 | 0.5321 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0162 | 0.4011 | 0.6396 |
Toxoplasma gondii | IMP dehydrogenas | 0.0194 | 0.5321 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0162 | 0.4011 | 0.6984 |
Trypanosoma cruzi | GMP reductase | 0.0194 | 0.5321 | 0.2979 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0194 | 0.5321 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0194 | 0.5321 | 0.2979 |
Trypanosoma cruzi | GMP reductase | 0.0194 | 0.5321 | 0.2979 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0194 | 0.5321 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0307 | 1 | 1 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0194 | 0.5321 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.