Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | gabp alpha | 0.0077 | 0.1482 | 0.1482 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3347 | 0.3347 |
Brugia malayi | RNA binding protein | 0.0134 | 0.3347 | 0.5067 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.2442 | 0.2442 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | TAR-binding protein | 0.0134 | 0.3347 | 0.3347 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0066 | 0.0066 |
Echinococcus multilocularis | geminin | 0.0179 | 0.4853 | 0.4853 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0111 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0066 | 0.0066 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0134 | 0.3347 | 0.3347 |
Brugia malayi | TAR-binding protein | 0.0134 | 0.3347 | 0.5067 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0336 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3347 | 0.3347 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0106 | 0.2442 | 0.2442 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0111 | 0.0111 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0066 | 0.0066 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.4853 | 0.4853 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0111 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0111 | 0.0111 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3347 | 0.3347 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0111 | 0.5 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0077 | 0.1482 | 0.1482 |
Loa Loa (eye worm) | RNA binding protein | 0.0134 | 0.3347 | 0.3347 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1342 | 0.1342 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0077 | 0.1482 | 0.1482 |
Echinococcus multilocularis | GPCR, family 2 | 0.0034 | 0.0066 | 0.0066 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0134 | 0.3347 | 0.5067 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.1117 | 0.1117 |
Plasmodium falciparum | importin beta, putative | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | fli-1 protein | 0.0233 | 0.6604 | 0.6604 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0066 | 0.0066 |
Echinococcus multilocularis | snurportin 1 | 0.0336 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0066 | 0.0066 |
Plasmodium vivax | importin-beta 2, putative | 0.0032 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3347 | 0.3347 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.0066 | 0.01 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.0066 | 0.01 |
Echinococcus granulosus | GPCR family 2 | 0.0034 | 0.0066 | 0.0066 |
Echinococcus granulosus | tar DNA binding protein | 0.0134 | 0.3347 | 0.3347 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0111 | 0.0168 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.1342 | 0.1342 |
Schistosoma mansoni | ets-related | 0.0233 | 0.6604 | 0.6604 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0106 | 0.2442 | 0.3697 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0077 | 0.1482 | 0.1482 |
Brugia malayi | Fli-1 protein | 0.0233 | 0.6604 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.0066 | 0.0066 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0111 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0134 | 0.3347 | 0.3347 |
Schistosoma mansoni | hypothetical protein | 0.0336 | 1 | 1 |
Brugia malayi | RNA, U transporter 1 | 0.009 | 0.1906 | 0.2885 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0111 | 0.0111 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.1342 | 0.2032 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0106 | 0.2442 | 0.3697 |
Echinococcus granulosus | geminin | 0.0179 | 0.4853 | 0.4853 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0111 | 0.0111 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0066 | 0.0066 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0032 | 0 | 0.5 |
Brugia malayi | Ets-domain containing protein | 0.0077 | 0.1482 | 0.2244 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.4853 | 0.4853 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0066 | 0.0066 |
Brugia malayi | Ets-domain containing protein | 0.0077 | 0.1482 | 0.2244 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3347 | 0.3347 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.