Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.079 | 0.4499 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.079 | 0.4499 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.079 | 0.4499 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.079 | 0.4499 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.079 | 0.4499 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.079 | 0.4499 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.079 | 0.4499 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.079 | 0.4499 | 0.5 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.079 | 0.4499 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.079 | 0.4499 | 0.4499 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.079 | 0.4499 | 1 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0333 | 0.0726 | 0.0726 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.079 | 0.4499 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0351 | 0.0874 | 0.0394 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.079 | 0.4499 | 1 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.079 | 0.4499 | 0.5 |
Plasmodium vivax | RNA helicase-1, putative | 0.079 | 0.4499 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.079 | 0.4499 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0351 | 0.0874 | 0.0394 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.079 | 0.4499 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.079 | 0.4499 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0351 | 0.0874 | 0.0874 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.079 | 0.4499 | 1 |
Brugia malayi | eukaryotic initiation factor 4A | 0.079 | 0.4499 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.079 | 0.4499 | 0.4499 |
Treponema pallidum | ATP-dependent RNA helicase | 0.079 | 0.4499 | 0.5 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.079 | 0.4499 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.079 | 0.4499 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 81 nM | Inhibitory activity against human recombinant carbonic anhydrase II (CA2) | ChEMBL. | 12039560 |
Ki (binding) | = 310 nM | Inhibitory activity against bovine carbonic anhydrase IV (CA4), obtained from bovine lung microsomes | ChEMBL. | 12039560 |
Ki (binding) | = 625 nM | Inhibitory activity against human recombinant carbonic anhydrase I (CA1) | ChEMBL. | 12039560 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.