Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.2922 | 0.695 | 0.695 |
Brugia malayi | hypothetical protein | 0.1219 | 0.2059 | 0.2963 |
Loa Loa (eye worm) | hypothetical protein | 0.1219 | 0.2059 | 0.2963 |
Brugia malayi | prolyl oligopeptidase family protein | 0.2498 | 0.5731 | 0.8247 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.2498 | 0.5731 | 1 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.2498 | 0.5731 | 0.5731 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.2922 | 0.695 | 0.695 |
Brugia malayi | prolyl oligopeptidase family protein | 0.2922 | 0.695 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.2922 | 0.695 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.2922 | 0.695 | 0.695 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.3984 | 1 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.2498 | 0.5731 | 0.5731 |
Loa Loa (eye worm) | hypothetical protein | 0.1278 | 0.2229 | 0.3207 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.2498 | 0.5731 | 1 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.3984 | 1 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.2922 | 0.695 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.2498 | 0.5731 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.2498 | 0.5731 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.2498 | 0.5731 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.1609 | 0.3178 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.2498 | 0.5731 | 0.5731 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Glucose normalisation (functional) | = 9 % | Percentage glucose normalization relative to the ciglitazone effect at 50 mg/kg, which lower blood glucose levels to that of the lean littermates at the dose 1 mg/kg (in mice) | ChEMBL. | 2033578 |
Glucose normalisation (functional) | = 9 % | Percentage glucose normalization relative to the ciglitazone effect at 50 mg/kg, which lower blood glucose levels to that of the lean littermates at the dose 1 mg/kg (in mice) | ChEMBL. | 2033578 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.