Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.7481 | 0.3291 | 0.5 |
Echinococcus multilocularis | conserved hypothetical protein | 1.3527 | 0.9848 | 1 |
Onchocerca volvulus | 0.7481 | 0.3291 | 0.5 | |
Brugia malayi | Serotonin receptor | 0.9158 | 0.5109 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.7481 | 0.3291 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 4.89 | pKi value expresses binding affinity against thermolysin pKi = -logKi (where Ki is in mol/L) | ChEMBL. | 11931613 |
Log Ki (binding) | = 4.89 | pKi value expresses binding affinity against thermolysin pKi = -logKi (where Ki is in mol/L) | ChEMBL. | 11931613 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.