Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0867 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0339 | 0.356 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0867 | 1 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0116 | 0.0844 | 0.0924 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0339 | 0.356 | 0.39 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0867 | 1 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0867 | 1 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.0867 | 1 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0867 | 1 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0339 | 0.356 | 0.356 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0867 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0867 | 1 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0386 | 0.4143 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0867 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0339 | 0.356 | 0.39 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0867 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0339 | 0.356 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0867 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0081 | 0.042 | 0.042 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0867 | 1 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0386 | 0.4143 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0116 | 0.0844 | 0.2369 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0339 | 0.356 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0867 | 1 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0796 | 0.9129 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0116 | 0.0844 | 0.0844 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0867 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.