Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | geranylgeranyl pyrophosphate synthase | 0.0427 | 1 | 1 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.0427 | 1 | 1 |
Onchocerca volvulus | 0.0172 | 0.2008 | 1 | |
Echinococcus granulosus | geranylgeranyl pyrophosphate synthase | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | geranylgeranyl pyrophosphate synthetase | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0172 | 0.2008 | 0.2008 |
Entamoeba histolytica | hexokinase 1 | 0.0172 | 0.2008 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0172 | 0.2008 | 0.2008 |
Onchocerca volvulus | 0.0172 | 0.2008 | 1 | |
Trypanosoma brucei | hexokinase | 0.0172 | 0.2008 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0172 | 0.2008 | 0.5 |
Schistosoma mansoni | geranylgeranyl pyrophosphate synthase | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0295 | 0.0295 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.0427 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0172 | 0.2008 | 0.5 |
Brugia malayi | hexokinase | 0.0172 | 0.2008 | 0.2008 |
Trypanosoma brucei | hexokinase, putative | 0.0172 | 0.2008 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0172 | 0.2008 | 0.2008 |
Plasmodium vivax | hexokinase, putative | 0.0172 | 0.2008 | 0.5 |
Onchocerca volvulus | 0.0172 | 0.2008 | 1 | |
Treponema pallidum | octaprenyl-diphosphate synthase | 0.0427 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0172 | 0.2008 | 0.2008 |
Toxoplasma gondii | hexokinase | 0.0172 | 0.2008 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0172 | 0.2008 | 0.5 |
Leishmania major | polyprenyl synthase, putative | 0.0427 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.91 uM | Binding affinity against muscarinic acetylcholine receptor from rat brain crude membrane, using [3H]-OXO-M (oxotremorine) as the radioligand. | ChEMBL. | 7739014 |
Ki (binding) | = 34 uM | Binding affinity against muscarinic acetylcholine receptor from rat brain crude membrane, using [3H]-NMS (N-Methylscopolamine) as the radioligand. | ChEMBL. | 7739014 |
Ratio (binding) | = 37.4 | Ratio of the Ki (NMS) value to that of Ki (Oxo-M). | ChEMBL. | 7739014 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.