Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0728 | 0.9163 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0096 | 0.0659 | 0.0659 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.0198 | 0.0167 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0728 | 0.9163 | 1 |
Onchocerca volvulus | 0.0272 | 0.3027 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0728 | 0.9163 | 1 |
Echinococcus granulosus | expressed conserved protein | 0.009 | 0.058 | 0.3767 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.0198 | 0.0167 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0096 | 0.0659 | 0.4538 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0659 | 0.0672 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0096 | 0.0659 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0137 | 0.1213 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0097 | 0.0679 | 1 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0096 | 0.0659 | 0.0513 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.0198 | 0.0167 |
Echinococcus multilocularis | expressed conserved protein | 0.009 | 0.058 | 0.058 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0728 | 0.9163 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 0.4374 | 0.4747 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.0198 | 0.0198 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0728 | 0.9163 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0137 | 0.1213 | 0.1213 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.