Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.8975 | 0.8975 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 1 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.8975 | 0.8975 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.8975 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0047 | 0.4312 | 0.4312 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.8975 | 0.8975 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.8975 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0061 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0037 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.8975 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0047 | 0.4312 | 0.4312 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.8975 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.8975 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.8975 | 0.8975 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.8975 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0037 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.