Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | mitochondrial DNA polymerase beta | 0.0305 | 0.8693 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1648 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0341 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.011 | 0.1648 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.011 | 0.1648 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0187 | 0.4426 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0305 | 0.8693 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.0396 | 0.0896 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0075 | 0.0396 | 0.2405 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0396 | 0.2405 |
Echinococcus granulosus | cyclin dependent kinase 6 | 0.0187 | 0.4426 | 0.4426 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.011 | 0.1648 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0161 | 0.3487 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0274 | 0.7564 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0305 | 0.8693 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0305 | 0.8693 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 6 | 0.0187 | 0.4426 | 0.4426 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.