Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.734 | 0.8042 |
Echinococcus granulosus | cyclin dependent kinase 6 | 0.0188 | 0.8261 | 1 |
Echinococcus multilocularis | geminin | 0.0168 | 0.734 | 0.8042 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0188 | 0.8261 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0415 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.0415 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0415 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.009 | 0.3554 | 0.3275 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.009 | 0.3554 | 0.3554 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0415 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0415 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0415 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.0415 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.734 | 0.8042 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0415 | 0.0415 |
Echinococcus granulosus | geminin | 0.0168 | 0.734 | 0.8042 |
Echinococcus multilocularis | cyclin dependent kinase 6 | 0.0188 | 0.8261 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.0415 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0224 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.