Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.1592 | 0.4094 | 0.4094 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.3731 | 1 | 1 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0108 | 0 | 0.5 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.3731 | 1 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0321 | 0.0586 | 0.0586 |
Onchocerca volvulus | 0.0964 | 0.2362 | 1 | |
Echinococcus granulosus | 6 phosphofructokinase | 0.0108 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0427 | 0.0878 | 0.0878 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.3731 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.3731 | 1 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0427 | 0.0878 | 0.0878 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0302 | 0.0302 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.3731 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0317 | 0.0575 | 0.0575 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.3731 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.0586 | 0.0586 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0427 | 0.0878 | 1 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.3731 | 1 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0427 | 0.0878 | 0.0878 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0108 | 0 | 0.5 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.3731 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0321 | 0.0586 | 1 |
Brugia malayi | hypothetical protein | 0.0121 | 0.0036 | 0.0036 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.3731 | 1 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.1592 | 0.4094 | 0.4094 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.0586 | 0.0586 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0108 | 0 | 0.5 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0108 | 0 | 0.5 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.3731 | 1 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0427 | 0.0878 | 1 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0108 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0321 | 0.0586 | 1 |
Onchocerca volvulus | 0.0321 | 0.0586 | 0.0725 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC o (ADMET) | = 7.2 uM hr | Area under the plasma concentration-time curve of the compound in rats following oral administration at 20 mg/kg | ChEMBL. | 15027850 |
Cmax (functional) | = 1 uM | Maximum plasma concentration of the compound in rats following oral administration at 20 mg/kg | ChEMBL. | 15027850 |
EC50 (functional) | = 1 nM | Inhibition of hepatitis C virus in a cell based HCV replicon assay. | ChEMBL. | 15027850 |
IC50 (binding) | = 2.9 nM | Inhibitory concentration against hepatitis C virus NS3 protease | ChEMBL. | 15027850 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.