Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.0081 | 0.1407 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0081 | 0.1407 | 0.1561 |
Echinococcus multilocularis | carbonic anhydrase | 0.0081 | 0.1407 | 0.1047 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0172 | 0.5162 | 0.5728 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0092 | 0.1858 | 0.2122 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0114 | 0.2756 | 0.2719 |
Echinococcus granulosus | carbonic anhydrase II | 0.0172 | 0.5162 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0172 | 0.5162 | 0.5214 |
Mycobacterium ulcerans | glutaminase | 0.0266 | 0.9012 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0172 | 0.5162 | 0.4644 |
Schistosoma mansoni | glutaminase | 0.0266 | 0.9012 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0081 | 0.1407 | 0.0546 |
Chlamydia trachomatis | sulfite reductase | 0.007 | 0.0968 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0114 | 0.2756 | 0.4264 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0114 | 0.2756 | 0.2719 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0081 | 0.1407 | 0.0546 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0114 | 0.2756 | 0.1256 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0114 | 0.2756 | 0.2719 |
Brugia malayi | glutaminase DH11.1 | 0.0266 | 0.9012 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.007 | 0.0968 | 0.1074 |
Brugia malayi | flavodoxin family protein | 0.0114 | 0.2756 | 0.2223 |
Leishmania major | p450 reductase, putative | 0.0114 | 0.2756 | 0.2719 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0092 | 0.1858 | 0.0985 |
Brugia malayi | FAD binding domain containing protein | 0.0114 | 0.2756 | 0.2223 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0114 | 0.2756 | 0.4264 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0172 | 0.5162 | 0.4644 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0081 | 0.1407 | 0.1561 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0172 | 0.5162 | 0.5728 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0081 | 0.1407 | 0.1561 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0081 | 0.1407 | 0.0546 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0114 | 0.2756 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0266 | 0.9012 | 0.8906 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0172 | 0.5162 | 0.5214 |
Leishmania major | cytochrome P450 reductase, putative | 0.0101 | 0.2225 | 0.1111 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1407 | 0.0486 |
Trypanosoma cruzi | p450 reductase, putative | 0.0114 | 0.2756 | 0.2719 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0101 | 0.2225 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0172 | 0.5162 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0081 | 0.1407 | 0.1047 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0057 | 0.0436 | 0.0484 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.2756 | 0.198 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0172 | 0.5162 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0172 | 0.5162 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0081 | 0.1407 | 0.1047 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0114 | 0.2756 | 0.2719 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1407 | 0.0486 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0081 | 0.1407 | 0.0546 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0092 | 0.1858 | 0.5 |
Trichomonas vaginalis | glutaminase, putative | 0.0266 | 0.9012 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0266 | 0.9012 | 0.8906 |
Schistosoma mansoni | carbonic anhydrase | 0.0081 | 0.1407 | 0.1561 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0101 | 0.2225 | 0.0513 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1407 | 0.0486 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0092 | 0.1858 | 0.2122 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0114 | 0.2756 | 0.4264 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0092 | 0.1858 | 0.2061 |
Giardia lamblia | Hypothetical protein | 0.0101 | 0.2225 | 1 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0057 | 0.04 | 0.0444 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0172 | 0.5162 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0114 | 0.2756 | 0.2719 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0114 | 0.2756 | 0.2719 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0172 | 0.5162 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0081 | 0.1407 | 0.0546 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0081 | 0.1407 | 0.0486 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0114 | 0.2756 | 0.4264 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0114 | 0.2756 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0114 | 0.2756 | 0.2719 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0114 | 0.2756 | 0.3058 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0092 | 0.1858 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.1407 | 0.1561 |
Echinococcus multilocularis | carbonic anhydrase | 0.0081 | 0.1407 | 0.1047 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0114 | 0.2756 | 0.2719 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0114 | 0.2756 | 0.198 |
Echinococcus granulosus | carbonic anhydrase | 0.0081 | 0.1407 | 0.1047 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0092 | 0.1858 | 0.1106 |
Echinococcus granulosus | carbonic anhydrase | 0.0081 | 0.1407 | 0.1047 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -1.2 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = -0.54 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = -0.01 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 4 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 10 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 14 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 93 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 7.64 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 4 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 10 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 14 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 93 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 5.99 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 1.03207 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.