Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | thymidylate synthase | 0.0195 | 0.0474 | 0.3831 |
Brugia malayi | hypothetical protein | 0.0093 | 0.0066 | 0.0529 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.0474 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.0474 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.036 | 0.1137 | 1 |
Brugia malayi | Kinesin motor domain containing protein | 0.0334 | 0.1033 | 0.8346 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0112 | 0.0142 | 0.1145 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0334 | 0.1033 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0195 | 0.0474 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0385 | 0.1238 | 1 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0334 | 0.1033 | 0.8346 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.0474 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0112 | 0.0142 | 0.0142 |
Schistosoma mansoni | kinesin eg-5 | 0.0334 | 0.1033 | 0.1193 |
Echinococcus granulosus | voltage gated potassium channel | 0.0112 | 0.0142 | 0.0142 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0385 | 0.1238 | 1 |
Schistosoma mansoni | hypothetical protein | 0.2238 | 0.8661 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0421 | 0.138 | 0.1593 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0385 | 0.1238 | 0.1238 |
Plasmodium falciparum | kinesin-5 | 0.0334 | 0.1033 | 1 |
Plasmodium vivax | kinesin-5 | 0.0334 | 0.1033 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.036 | 0.1137 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0334 | 0.1034 | 0.8354 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0093 | 0.0066 | 0.0577 |
Echinococcus granulosus | thymidylate synthase | 0.0195 | 0.0474 | 0.0474 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0385 | 0.1238 | 0.1238 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0142 | 0.1145 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0195 | 0.0474 | 1 |
Giardia lamblia | Kinesin-5 | 0.0334 | 0.1033 | 0.5 |
Entamoeba histolytica | kinesin, putative | 0.0334 | 0.1033 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0112 | 0.0142 | 0.0164 |
Onchocerca volvulus | 0.0195 | 0.0474 | 0.5 | |
Echinococcus multilocularis | kinesin family 1 | 0.2572 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0112 | 0.0142 | 0.0164 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0421 | 0.138 | 0.1593 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0112 | 0.0142 | 0.0142 |
Brugia malayi | thymidylate synthase | 0.0195 | 0.0474 | 0.3831 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0112 | 0.0142 | 0.0142 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.0474 | 0.0548 |
Mycobacterium ulcerans | thymidylate synthase | 0.0195 | 0.0474 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0195 | 0.0474 | 0.0474 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.94 uM | In vitro inhibition of partially purified L1210 thymidylate synthase (TS). | ChEMBL. | 2033585 |
IC50 (binding) | = 0.94 uM | In vitro inhibition of partially purified L1210 thymidylate synthase (TS). | ChEMBL. | 2033585 |
IC50 (functional) | = 2.4 uM | In vitro inhibition of L1210 cell growth in culture. | ChEMBL. | 2033585 |
IC50 (functional) | = 2.4 uM | In vitro inhibition of L1210 cell growth in culture. | ChEMBL. | 2033585 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 2033585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.