Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.5093 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0102 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 1 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.5093 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.5093 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.5093 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.5093 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.5093 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.5093 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.5093 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.5093 | 0.5093 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0102 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.5093 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC90 (functional) | = 0.007 uM | In vitro relaxation of de-endothelialized rat aortic strips toned with 20 mM KCl | ChEMBL. | 8496928 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.