Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tachykinin receptor 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04224 tachykinin receptor 3, putative | Get druggable targets OG5_137770 | All targets in OG5_137770 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Glycogen phosphorylase | 0.0327 | 0.3677 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0103 | 0 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0327 | 0.3677 | 0.3302 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0327 | 0.3677 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0327 | 0.3677 | 0.3302 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0714 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0327 | 0.3677 | 1 |
Brugia malayi | carbohydrate phosphorylase | 0.0327 | 0.3677 | 0.3302 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0714 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0327 | 0.3677 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0327 | 0.3677 | 0.3302 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0714 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0327 | 0.3677 | 0.5 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0142 | 0.0638 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0327 | 0.3677 | 0.3677 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0714 | 1 | 1 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0142 | 0.0638 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0327 | 0.3677 | 0.3302 |
Echinococcus granulosus | glycogen phosphorylase | 0.0327 | 0.3677 | 0.3302 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0327 | 0.3677 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0327 | 0.3677 | 0.3677 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0137 | 0.0559 | 0.0559 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0327 | 0.3677 | 0.3302 |
Schistosoma mansoni | glycogen phosphorylase | 0.0142 | 0.0638 | 0.0638 |
Echinococcus granulosus | glycogen phosphorylase | 0.0327 | 0.3677 | 0.3302 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0327 | 0.3677 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 210 nM | Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina | ChEMBL. | No reference |
IC50 (binding) | = 210 nM | Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.