Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0155 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0155 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0155 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0155 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0155 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0155 | 0.5 | 0.5 | |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0155 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0155 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0155 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0155 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0155 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0155 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0155 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0155 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0155 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0155 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0155 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0155 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0155 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0155 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0155 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0155 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0155 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0155 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0155 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0155 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0155 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0155 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0155 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0155 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0155 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0155 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0155 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0155 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0155 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0155 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0155 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0155 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0155 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0155 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0155 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0155 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0155 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0155 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0155 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0155 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0155 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0155 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0155 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0155 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0155 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0155 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 8 ng hr ml-1 | Area under the concentration-time curve for 0-4 h after 2 mg/kg po in rat | ChEMBL. | 11334570 |
Cmax (ADMET) | = 3 ng ml-1 | Maximum blood concentration after oral dosing at 2 mg/kg in rat | ChEMBL. | 11334570 |
Ki (binding) | = 0.09 nM | Ability to displace [3H]-ketanserin binding to human 5-hydroxytryptamine 2A receptor stably expressed in CHO cells | ChEMBL. | 11334570 |
Ki (binding) | = 3.9 nM | Ability to displace [3H]-prazosin binding to rat cortical membranes expressing Alpha-1 adrenergic receptors | ChEMBL. | 11334570 |
Ki (binding) | = 48 nM | Ability to displace [3H]-mesulergine binding to human 5-hydroxytryptamine 2C receptor stably expressed in CHO cells | ChEMBL. | 11334570 |
Ki (binding) | = 930 nM | Displacement of [3H]-dofetilide from HEK cells expressing hERG voltage dependent IKr potassium channel Kv11.1 | ChEMBL. | 11334570 |
Ki (binding) | > 1600 nM | Ability to displace [3H]-spiperone binding to CHO cells stably expressing dopamine receptor D2 | ChEMBL. | 11334570 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.