Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0442 | 1 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0442 | 1 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0442 | 1 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0442 | 1 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0442 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.0442 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0442 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0442 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0442 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0442 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0442 | 1 | 1 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0191 | 0 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0345 | 0.6141 | 0.6141 |
Echinococcus granulosus | glycogen phosphorylase | 0.0442 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0442 | 1 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0442 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0442 | 1 | 1 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0191 | 0 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0442 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Max fall in blood pressure (functional) | = -18 % | Oral antihypertensive activity in spontaneously hypertensive rats at a dose of 1 mg/kg (po) | ChEMBL. | 1578490 |
Max fall in blood pressure (functional) | = -15 % | Oral antihypertensive activity in spontaneously hypertensive rats at a dose of 3 mg/kg (po) | ChEMBL. | 1578490 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.