Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0001 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0216 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1681 | 0.1681 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0465 | 1 |
Schistosoma mansoni | beta-hexosaminidase B | 0.0216 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0001 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0216 | 1 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0465 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1724 | 0.1724 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0025 | 0.0025 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1681 | 0.1681 |
Onchocerca volvulus | Hexosaminidase D homolog | 0.005 | 0.1724 | 0.5 |
Echinococcus granulosus | beta hexosaminidase subunit beta | 0.0216 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0.0001 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0135 | 0.5956 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0465 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 20 | 0.0216 | 1 | 1 |
Schistosoma mansoni | beta-hexosaminidase B | 0.0216 | 1 | 1 |
Echinococcus multilocularis | beta hexosaminidase subunit alpha | 0.0135 | 0.5956 | 0.5956 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0001 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, alpha subunit | 0.0216 | 1 | 0.5 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0001 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0135 | 0.5956 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0465 | 0.0465 |
Brugia malayi | Glycosyl hydrolase family 20, catalytic domain containing protein | 0.005 | 0.1724 | 0.1724 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0001 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, beta subunit | 0.0216 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0903 | 0.0903 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1724 | 0.1724 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0001 | 0.0001 |
Echinococcus granulosus | beta hexosaminidase subunit alpha | 0.0135 | 0.5956 | 0.5956 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0001 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0903 | 0.0903 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0001 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1681 | 0.1681 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0465 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0465 | 1 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0135 | 0.5956 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0465 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0465 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0465 | 0.0465 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0903 | 0.0903 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0001 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0465 | 1 |
Brugia malayi | Glycosyl hydrolase family 20, catalytic domain containing protein | 0.005 | 0.1724 | 0.1724 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0001 |
Trichomonas vaginalis | beta-hexosaminidase B, putative | 0.0135 | 0.5956 | 1 |
Echinococcus multilocularis | beta hexosaminidase subunit beta | 0.0216 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1681 | 0.1681 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 3 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 5 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 5.17 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 5.64 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 6 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 6.51 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 96 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 0.76 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 3 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 5 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 6 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 96 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.84 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.14482 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.