Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0023 | 0.0861 | 0.1063 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.00233739 | 0.102513 | 0.132627 |
Brugia malayi | Glutamate receptor 2 precursor | 0.002 | 0.0419 | 0.5 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.00233739 | 0.102513 | 0.132627 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.00233739 | 0.102513 | 0.132627 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.00233739 | 0.102513 | 0.132627 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0070922 | 0.772941 | 1 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.00196467 | 0.0499602 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0023 | 0.0861 | 0.1063 |
Echinococcus granulosus | glutamate receptor 2 | 0.00233739 | 0.102513 | 0.132627 |
Echinococcus multilocularis | glutamate receptor 2 | 0.00233739 | 0.102513 | 0.132627 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0023 | 0.0861 | 0.1063 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.002 | 0.0419 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.00636516 | 0.670429 | 0.867373 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.00196467 | 0.0499602 | 0.0646364 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0023 | 0.0861 | 0.1063 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.00196467 | 0.0499602 | 0.0646364 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.00233739 | 0.102513 | 0.132627 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0023 | 0.0861 | 0.1063 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0023 | 0.0861 | 0.1063 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0070922 | 0.772941 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.002 | 0.0419 | 0.0518 |
Schistosoma mansoni | glutamate receptor NMDA | 0.00870255 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0023 | 0.0861 | 0.1063 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.002 | 0.0419 | 0.0518 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0023 | 0.0861 | 0.1063 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.002 | 0.0419 | 0.0518 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0084 | 0.8094 | 1 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.00636516 | 0.670429 | 0.867373 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.00233739 | 0.102513 | 0.132627 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0023 | 0.0861 | 0.1063 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0081 | 0.7674 | 0.9482 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.00233739 | 0.102513 | 0.132627 |
Echinococcus granulosus | nmda type glutamate receptor | 0.00673787 | 0.722981 | 0.935363 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0084 | 0.8094 | 1 |
Brugia malayi | Glutamate receptor 1 precursor | 0.00196467 | 0.0499602 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0023 | 0.0861 | 0.1063 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.00673787 | 0.722981 | 0.935363 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0077 | 0.7233 | 0.8937 |
Brugia malayi | Glutamate receptor 2 precursor | 0.00196467 | 0.0499602 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.00233739 | 0.102513 | 0.132627 |
Echinococcus multilocularis | glutamate receptor 2 | 0.00196467 | 0.0499602 | 0.0646364 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0081 | 0.7674 | 0.9482 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0077 | 0.7233 | 0.8937 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.002 | 0.0419 | 0.5 |
Brugia malayi | Glutamate receptor 1 precursor | 0.002 | 0.0419 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.00196467 | 0.0499602 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. | ChEMBL. | 22096101 | |
CC50 (functional) | > 100 uM | Huh7 cytotoxicity for Pf inhibitors | Novartis-GNF Malaria Box. | No reference |
CC50 | > 100 uM | NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) | ChEMBL. | 18579783 |
EC50 (functional) | > 2.477 uM | PF proliferation inhibition 3D7 | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | > 2.477 uM | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
EC50 (functional) | > 12.5 uM | W2 Pf proliferation inhibition | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | > 12.5 uM | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
IFI promiscuity index | = 0 | IFI promiscuity index | Novartis-GNF Malaria Box. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18579783 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.