Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 822 aa | 23.2 % |
Drosophila melanogaster | NMDA receptor 2 | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 878 aa | 27.4 % |
Drosophila melanogaster | Glutamate receptor IA | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 979 aa | 23.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0083 | 0.0461 | 0.0532 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0083 | 0.0461 | 0.0532 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.02 | 0.6314 | 0.7298 |
Echinococcus granulosus | nmda type glutamate receptor | 0.02 | 0.6314 | 0.7298 |
Echinococcus granulosus | glutamate receptor NMDA | 0.019 | 0.5854 | 0.6766 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0083 | 0.0461 | 0.0532 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0083 | 0.0461 | 0.0532 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.019 | 0.5854 | 0.6766 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0083 | 0.0461 | 0.0532 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0074 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0083 | 0.0461 | 0.0532 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0083 | 0.0461 | 0.0532 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0074 | 0 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0074 | 0 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0246 | 0.8652 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0083 | 0.0461 | 0.0532 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0083 | 0.0461 | 0.0532 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0246 | 0.8652 | 1 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0074 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0083 | 0.0461 | 0.0532 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.82 | Compound was tested for inhibition of [3H]-DCKA binding to N-methyl-D-aspartate glutamate receptor | ChEMBL. | 12699379 |
IC50 (binding) | = 0.15 uM | Inhibition of [3H]-DCKA binding to N-methyl-D-aspartate glutamate receptor | ChEMBL. | 12699379 |
IC50 (binding) | = 0.15 uM | Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain cortical membranes. | ChEMBL. | 9057859 |
IC50 (binding) | = 0.15 uM | Inhibition of [3H]-DCKA binding to N-methyl-D-aspartate glutamate receptor | ChEMBL. | 12699379 |
IC50 (binding) | = 0.15 uM | Potency for the N-methyl-D-aspartate glutamate receptor 1 glycine site by displacement of [3H]5,7-dichlorokynurenic acid (DCKA) binding in rat brain cortical membranes. | ChEMBL. | 9057859 |
Log (binding) | = 0.82 1/IC50 | Compound was tested for inhibition of [3H]-DCKA binding to N-methyl-D-aspartate glutamate receptor | ChEMBL. | 12699379 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.