Blood level (functional)
|
= 0.2 ug ml-1
|
Blood level was evaluated at 24.0 hr when administered at a peroral dose of 25 mg/kg
|
ChEMBL.
|
2840501
|
Blood level (functional)
|
= 0.2 ug ml-1
|
Blood level was evaluated at 24.0 hr when administered at a peroral dose of 25 mg/kg
|
ChEMBL.
|
2840501
|
Blood level (functional)
|
= 1.3 ug ml-1
|
Blood level was evaluated at 6.0 hr when administered at a peroral dose of 25 mg/kg
|
ChEMBL.
|
2840501
|
Blood level (functional)
|
= 1.3 ug ml-1
|
Blood level was evaluated at 6.0 hr when administered at a peroral dose of 25 mg/kg
|
ChEMBL.
|
2840501
|
Blood level (functional)
|
= 2.8 ug ml-1
|
Blood level was evaluated at 3.0 hh when administered at a peroral dose of 25 mg/kg
|
ChEMBL.
|
2840501
|
Blood level (functional)
|
= 2.8 ug ml-1
|
Blood level was evaluated at 3.0 hh when administered at a peroral dose of 25 mg/kg
|
ChEMBL.
|
2840501
|
Blood level (functional)
|
= 3.2 ug ml-1
|
Blood level was evaluated at 1.0 hr when administered at a peroral dose of 25 mg/kg
|
ChEMBL.
|
2840501
|
Blood level (functional)
|
= 3.2 ug ml-1
|
Blood level was evaluated at 1.0 hr when administered at a peroral dose of 25 mg/kg
|
ChEMBL.
|
2840501
|
Blood level (functional)
|
= 3.3 ug ml-1
|
Blood level was evaluated at 2.0 hr when administered at a peroral dose of 25 mg/kg
|
ChEMBL.
|
2840501
|
Blood level (functional)
|
= 3.3 ug ml-1
|
Blood level was evaluated at 2.0 hr when administered at a peroral dose of 25 mg/kg
|
ChEMBL.
|
2840501
|
Blood level (functional)
|
= 5.9 ug ml-1
|
Blood level was evaluated by a disk agar diffusion assay at 0.5 hr when administered at a peroral dose of 25 mg/kg
|
ChEMBL.
|
2840501
|
Blood level (functional)
|
= 5.9 ug ml-1
|
Blood level was evaluated by a disk agar diffusion assay at 0.5 hr when administered at a peroral dose of 25 mg/kg
|
ChEMBL.
|
2840501
|
ED50 (functional)
|
= 0.6 mg kg-1
|
In vivo efficacy against Escherichia coli Juhl, in mouse protection test when administered subcutaneously (sc)
|
ChEMBL.
|
2840501
|
ED50 (functional)
|
= 0.6 mg kg-1
|
In vivo efficacy against Escherichia coli Juhl, in mouse protection test when administered subcutaneously (sc)
|
ChEMBL.
|
2840501
|
ED50 (functional)
|
= 0.9 mg kg-1
|
In vivo efficacy against Staphylococcus aureus 10649, in mouse protection test when administered subcutaneously (sc)
|
ChEMBL.
|
2840501
|
ED50 (functional)
|
= 0.9 mg kg-1
|
In vivo efficacy against Staphylococcus aureus 10649, in mouse protection test when administered subcutaneously (sc)
|
ChEMBL.
|
2840501
|
ED50 (functional)
|
> 2.5 mg kg-1
|
In vivo efficacy against Staphylococcus aureus 10649, in mouse protection test when administered perorally (po)
|
ChEMBL.
|
2840501
|
ED50 (functional)
|
> 2.5 mg kg-1
|
In vivo efficacy against Staphylococcus aureus 10649, in mouse protection test when administered perorally (po)
|
ChEMBL.
|
2840501
|
ED50 (functional)
|
= 2.7 mg kg-1
|
In vivo efficacy against Escherichia coli Juhl, in mouse protection test when the administered perorally (po)
|
ChEMBL.
|
2840501
|
ED50 (functional)
|
= 2.7 mg kg-1
|
In vivo efficacy against Escherichia coli Juhl, in mouse protection test when the administered perorally (po)
|
ChEMBL.
|
2840501
|
I50 (functional)
|
= 0.6 ug ml-1
|
Supercoiling inhibition assay using purified DNA gyrase isolated from Escherichia coli H560
|
ChEMBL.
|
2840501
|
IC50 (functional)
|
= 0.6 ug ml-1
|
Supercoiling inhibition assay using purified DNA gyrase isolated from Escherichia coli H560
|
ChEMBL.
|
2840501
|
logP (ADMET)
|
= -0.2
|
Partition coefficient (logP)
|
ChEMBL.
|
2840501
|
MIC (functional)
|
= 0.02 ug ml-1
|
In vitro Minimum inhibitory concentration against Staphylococcus aureus ATCC 6538P
|
ChEMBL.
|
2840501
|
MIC (functional)
|
= 0.02 ug ml-1
|
In vitro Minimum inhibitory concentration against Staphylococcus aureus CMX 686B
|
ChEMBL.
|
2840501
|
MIC (functional)
|
= 0.02 ug ml-1
|
In vitro Minimum inhibitory concentration against Escherichia coli Juhl
|
ChEMBL.
|
2840501
|
MIC (functional)
|
= 0.02 ug ml-1
|
In vitro Minimum inhibitory concentration against Klebsiella pneumoniae 8045
|
ChEMBL.
|
2840501
|
MIC (functional)
|
= 0.02 ug ml-1
|
In vitro Minimum inhibitory concentration against Escherichia coli Juhl
|
ChEMBL.
|
2840501
|
MIC (functional)
|
= 0.05 ug ml-1
|
In vitro Minimum inhibitory concentration against Staphylococcus aureus A5177
|
ChEMBL.
|
2840501
|
MIC (functional)
|
= 0.05 ug ml-1
|
In vitro Minimum inhibitory concentration against Staphylococcus aureus 45
|
ChEMBL.
|
2840501
|
MIC (functional)
|
= 0.05 ug ml-1
|
In vitro Minimum inhibitory concentration against S. epidermidis 3519
|
ChEMBL.
|
2840501
|
MIC (functional)
|
= 0.1 ug ml-1
|
In vitro Minimum inhibitory concentration against S. faecium ATCC 8043
|
ChEMBL.
|
2840501
|
MIC (functional)
|
= 0.1 ug ml-1
|
In vitro Minimum inhibitory concentration against Acinetobacter CMX 669
|
ChEMBL.
|
2840501
|
MIC (functional)
|
= 0.2 ug ml-1
|
In vitro Minimum inhibitory concentration against S. bovis A5169
|
ChEMBL.
|
2840501
|
MIC (functional)
|
= 0.2 ug ml-1
|
In vitro Minimum inhibitory concentration against S. agalactiae CMX 508
|
ChEMBL.
|
2840501
|
MIC (functional)
|
= 0.2 ug ml-1
|
In vitro Minimum inhibitory concentration against S. pyogenes 930
|
ChEMBL.
|
2840501
|
MIC (functional)
|
= 0.78 ug ml-1
|
In vitro Minimum inhibitory concentration against Pseudomonas aeruginosa 5007
|
ChEMBL.
|
2840501
|
MIC (functional)
|
= 0.78 ug ml-1
|
In vitro Minimum inhibitory concentration against Pseudomonas aeruginosa K799/WT
|
ChEMBL.
|
2840501
|
Solubility (ADMET)
|
= 0.15 mg ml-1
|
Compound was evaluated for the solubility in Ringer's buffer solution
|
ChEMBL.
|
2840501
|