Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0218 | 0.0569 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.0929 | 0.089 |
Echinococcus granulosus | FTZ F1 alpha | 0.041 | 0.5732 | 0.5713 |
Loa Loa (eye worm) | glutaminase | 0.0266 | 0.3543 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0047 | 0.0218 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0268 | 0.071 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0043 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.0929 | 0.0914 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0251 | 0.0663 |
Leishmania major | hypothetical protein, conserved | 0.005 | 0.0268 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.0929 | 0.0914 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0043 | 0.0121 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.0929 | 0.089 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0043 | 0.0026 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0043 | 0.0026 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0251 | 0.0708 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0043 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.0929 | 0.0914 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0043 | 0.5 |
Loa Loa (eye worm) | glutaminase 2 | 0.0266 | 0.3543 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0047 | 0.0218 | 0.0201 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0043 | 0.5 |
Schistosoma mansoni | glutaminase | 0.0266 | 0.3543 | 0.3532 |
Leishmania major | DNA polymerase eta, putative | 0.0047 | 0.0218 | 0.8082 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.0268 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.0268 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0691 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.0268 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.005 | 0.0268 | 1 |
Onchocerca volvulus | 0.0158 | 0.1905 | 0.5 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.0929 | 0.089 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.1905 | 0.5353 |
Schistosoma mansoni | hypothetical protein | 0.0691 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0251 | 0.0663 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0251 | 0.0708 |
Trichomonas vaginalis | glutaminase, putative | 0.0266 | 0.3543 | 0.5 |
Brugia malayi | hypothetical protein | 0.005 | 0.0268 | 0.0755 |
Echinococcus granulosus | dna polymerase eta | 0.0047 | 0.0218 | 0.0176 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.005 | 0.0268 | 1 |
Brugia malayi | hypothetical protein | 0.0158 | 0.1905 | 0.5376 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0047 | 0.0218 | 0.0615 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.0268 | 0.5 |
Mycobacterium ulcerans | glutaminase | 0.0266 | 0.3543 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0017 | 0.0049 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0093 | 0.0929 | 0.2586 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.0929 | 0.089 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.005 | 0.0268 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0047 | 0.0218 | 0.8082 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0093 | 0.0929 | 0.2622 |
Echinococcus multilocularis | geminin | 0.0691 | 1 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.0266 | 0.3543 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.