Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | References | |
Homo sapiens | glutamate receptor, ionotropic, N-methyl-D-aspartate 3B | References | |
Rattus norvegicus | Glutamate NMDA receptor | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 822 aa | 23.2 % |
Drosophila melanogaster | NMDA receptor 2 | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 878 aa | 27.4 % |
Drosophila melanogaster | Glutamate receptor IA | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 979 aa | 23.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nmda type glutamate receptor | 0.0293 | 0.8337 | 1 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0123 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0137 | 0.0675 | 0.081 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0137 | 0.0675 | 0.081 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0293 | 0.8337 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0137 | 0.0675 | 0.081 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0123 | 0 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0123 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0137 | 0.0675 | 0.081 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0137 | 0.0675 | 0.081 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0137 | 0.0675 | 0.081 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.019 | 0.3305 | 0.3965 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0123 | 0 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0137 | 0.0675 | 0.081 |
Echinococcus granulosus | glutamate receptor NMDA | 0.019 | 0.3305 | 0.3965 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0137 | 0.0675 | 0.081 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0137 | 0.0675 | 0.081 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0137 | 0.0675 | 0.081 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0204 | 0.3981 | 0.4775 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0204 | 0.3981 | 0.4775 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.28 | Compound was tested for inhibition of [3H]-DCKA binding to N-methyl-D-aspartate glutamate receptor | ChEMBL. | 12699379 |
IC50 (binding) | = 0.053 uM | Inhibition of [3H]-DCKA binding to NMDA receptor of rat brain membranes. | ChEMBL. | 8917657 |
IC50 (binding) | = 0.053 uM | Inhibition of [3H]-DCKA binding to N-methyl-D-aspartate glutamate receptor | ChEMBL. | 12699379 |
IC50 (binding) | = 0.053 uM | Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranes | ChEMBL. | 8765507 |
IC50 (binding) | = 0.053 uM | Inhibition of [3H]-DCKA binding to NMDA receptor of rat brain membranes. | ChEMBL. | 8917657 |
IC50 (binding) | = 0.053 uM | Inhibition of [3H]-DCKA binding to N-methyl-D-aspartate glutamate receptor | ChEMBL. | 12699379 |
IC50 (binding) | = 0.053 uM | Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranes | ChEMBL. | 8765507 |
Kb (functional) | = 0.086 uM | Functional antagonism of NR1a/2C N-methyl-D-aspartate glutamate receptor of rat membrane expressed in Xenopus oocytes | ChEMBL. | 8765507 |
Kb (binding) | = 0.74 uM | Inhibition of Ionotropic glutamate receptor AMPA in xenopus oocytes expressing the rat cerebral cortex poly(A+) RNA | ChEMBL. | 8765507 |
Kb (binding) | = 0.74 uM | Inhibition of Ionotropic glutamate receptor AMPA in xenopus oocytes expressing the rat cerebral cortex poly(A+) RNA | ChEMBL. | 8765507 |
Log (binding) | = 1.28 1/IC50 | Compound was tested for inhibition of [3H]-DCKA binding to N-methyl-D-aspartate glutamate receptor | ChEMBL. | 12699379 |
Selectivity (binding) | = 8.6 | Steady state Selectivity index for inhibition at NMDA receptor glycine site was estimated by dividing Kb (AMPA) by Kb (NMDA) | ChEMBL. | 8765507 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.