Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Acyl-CoA:cholesterol acyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Echinococcus granulosus | sterol O acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Schistosoma mansoni | sterol O-acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Echinococcus multilocularis | sterol O acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Schistosoma japonicum | ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Neospora caninum | sterol O-acyltransferase, putative | Acyl-CoA:cholesterol acyltransferase | 305 aa | 258 aa | 20.2 % |
Dictyostelium discoideum | diacylglycerol O-acyltransferase 1 | Acyl-CoA:cholesterol acyltransferase | 305 aa | 278 aa | 21.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.1855 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1855 | 0.5 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.1855 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1855 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cholesterol reduction (functional) | = 2 % | Tested for cholesterol lowering activity in rats after a dose of 50 mg/kg once a day for 2 days | ChEMBL. | 8496930 |
IC50 (binding) | = 0.87 uM | Tested for inhibition against acyl coenzyme A:cholesterol acyltransferase from rabbit intestine microsomes. | ChEMBL. | 8496930 |
IC50 (binding) | = 0.87 uM | Tested for inhibition against acyl coenzyme A:cholesterol acyltransferase from rabbit intestine microsomes. | ChEMBL. | 8496930 |
IC50 (binding) | > 10 uM | Tested for inhibition against acyl coenzyme A:cholesterol acyltransferase from rabbit aorta homogenate. | ChEMBL. | 8496930 |
IC50 (binding) | > 10 uM | Tested for inhibition against acyl coenzyme A:cholesterol acyltransferase from rabbit aorta homogenate. | ChEMBL. | 8496930 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.