TDR Targets

Basic information

Technical information

TDR Targets ID: 61596
Name: 4-(1-methyl-2-phenylindol-3-yl)cyclohexane-1, 1-dicarboxylic acid
MW: 377.433 | Formula: C23H23NO4
H donors: 2 H acceptors: 4 LogP: 4.4 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C1(CCC(CC1)c1c(c2ccccc2)n(c2c1cccc2)C)C(=O)O
InChi: 1S/C23H23NO4/c1-24-18-10-6-5-9-17(18)19(20(24)16-7-3-2-4-8-16)15-11-13-23(14-12-15,21(25)26)22(27)28/h2-10,15H,11-14H2,1H3,(H,25,26)(H,27,28)
InChiKey: IKEDBWCEDOXZQY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-(1-methyl-2-phenyl-indol-3-yl)cyclohexane-1,1-dicarboxylic acid
4-(1-methyl-2-phenyl-3-indolyl)cyclohexane-1,1-dicarboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0037	0.2327	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0037	0.2327	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Brugia malayi	GnHR receptor homolog	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Brugia malayi	hypothetical protein	0.0037	0.2327	1
Echinococcus granulosus	g protein coupled receptor	0.0037	0.2327	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0037	0.2327	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.2327	1
Schistosoma mansoni	opsin-like receptor	0.0037	0.2327	1
Schistosoma mansoni	neuropeptide receptor	0.0037	0.2327	1
Echinococcus granulosus	hypothetical protein	0.0037	0.2327	1
Onchocerca volvulus		0.0037	0.2327	1
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0029	0.1655	0.7111
Onchocerca volvulus		0.0037	0.2327	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0037	0.2327	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0037	0.2327	1
Brugia malayi	larval opioid receptor	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Echinococcus multilocularis	somatostatin receptor	0.0037	0.2327	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0037	0.2327	1
Schistosoma mansoni	opsin-like receptor	0.0037	0.2327	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.2327	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.2327	1
Onchocerca volvulus		0.0037	0.2327	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.2327	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0037	0.2327	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.2327	1
Schistosoma mansoni	neuropeptide receptor	0.0037	0.2327	1
Brugia malayi	hypothetical protein	0.0037	0.2327	1
Schistosoma mansoni	neuropeptide receptor	0.0037	0.2327	1
Brugia malayi	hypothetical protein	0.0037	0.2327	1
Brugia malayi	hypothetical protein	0.0037	0.2327	1
Brugia malayi	RE15519p	0.0037	0.2327	1
Echinococcus granulosus	neuropeptide Y receptor	0.0037	0.2327	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.2327	1
Echinococcus multilocularis	neuropeptide receptor	0.0037	0.2327	1
Brugia malayi	G-protein coupled receptor	0.0037	0.2327	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0037	0.2327	1
Echinococcus granulosus	g-protein coupled receptor	0.0037	0.2327	1
Brugia malayi	G protein-coupled receptor	0.0037	0.2327	1
Brugia malayi	follicle stimulating hormone receptor	0.0037	0.2327	1
Mycobacterium leprae	Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase)	0.0043	0.2859	0.5
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Onchocerca volvulus		0.0037	0.2327	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0037	0.2327	1
Onchocerca volvulus		0.0037	0.2327	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Schistosoma mansoni	biogenic amine receptor	0.0037	0.2327	1
Loa Loa (eye worm)	TYRA-2 protein	0.0037	0.2327	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0037	0.2327	1
Brugia malayi	hypothetical protein	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.2327	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0037	0.2327	1
Brugia malayi	Probable DNA topoisomerase II	0.0029	0.1655	0.7111
Schistosoma mansoni	hypothetical protein	0.0037	0.2327	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.2327	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0037	0.2327	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0037	0.2327	1
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0073	0.5404	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0037	0.2327	1
Brugia malayi	Serotonin receptor	0.0037	0.2327	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0037	0.2327	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0037	0.2327	1
Brugia malayi	hypothetical protein	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Brugia malayi	neuropeptide F receptor	0.0037	0.2327	1
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.2327	1
Trypanosoma brucei	DNA topoisomerase ii	0.0073	0.5404	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0037	0.2327	1
Echinococcus multilocularis	neuropeptide s receptor	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0029	0.1655	0.7111
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0037	0.2327	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0037	0.2327	1
Brugia malayi	Dopamine receptor	0.0037	0.2327	1
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0029	0.1655	0.7111
Onchocerca volvulus		0.0037	0.2327	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0037	0.2327	1
Schistosoma mansoni	neuropeptide receptor	0.0037	0.2327	1
Echinococcus granulosus	fmrfamide receptor	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Schistosoma mansoni	DNA topoisomerase II	0.0029	0.1655	0.7111
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0029	0.1655	0.7111
Echinococcus granulosus	neuropeptide receptor	0.0037	0.2327	1
Echinococcus multilocularis	serotonin receptor	0.0037	0.2327	1
Schistosoma mansoni	amine GPCR	0.0037	0.2327	1
Echinococcus multilocularis	fmrfamide receptor	0.0037	0.2327	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0037	0.2327	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0037	0.2327	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.2327	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0037	0.2327	1
Schistosoma mansoni	myosin xvIII	0.0037	0.2327	1
Brugia malayi	ORL1-like opioid receptor	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Onchocerca volvulus		0.0037	0.2327	1
Brugia malayi	hypothetical protein	0.0037	0.2327	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.2327	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0037	0.2327	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0037	0.2327	1
Echinococcus granulosus	neuropeptides capa receptor	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0876	0.3765
Echinococcus multilocularis	allatostatin A receptor	0.0037	0.2327	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0037	0.2327	1
Brugia malayi	hypothetical protein	0.0037	0.2327	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.2327	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0037	0.2327	1
Echinococcus granulosus	allatostatin A receptor	0.0037	0.2327	1
Onchocerca volvulus		0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Schistosoma mansoni	hypothetical protein	0.0037	0.2327	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.2327	1
Echinococcus granulosus	serotonin receptor	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Brugia malayi	Serotonin receptor	0.0037	0.2327	1
Brugia malayi	putative neuropeptide receptor	0.0037	0.2327	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.2327	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0037	0.2327	1
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0029	0.1655	0.7111
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Echinococcus granulosus	sex peptide receptor	0.0037	0.2327	1
Plasmodium falciparum	DNA gyrase subunit B	0.0126	1	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0037	0.2327	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Echinococcus granulosus	neuropeptide receptor	0.0037	0.2327	1
Giardia lamblia	DNA topoisomerase II	0.0026	0.1313	0.5
Onchocerca volvulus		0.0037	0.2327	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0037	0.2327	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0037	0.2327	1
Onchocerca volvulus		0.0037	0.2327	1
Schistosoma mansoni	histamine h1 receptor	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Echinococcus granulosus	neuropeptide s receptor	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.2327	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0037	0.2327	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0037	0.2327	1
Schistosoma mansoni	amine GPCR	0.0037	0.2327	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0037	0.2327	1
Echinococcus granulosus	orexin receptor type 2	0.0037	0.2327	1
Brugia malayi	neuropeptide F receptor	0.0037	0.2327	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.2327	1
Brugia malayi	Dopamine receptor protein 2	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0073	0.5404	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.2327	1
Brugia malayi	sulfakinin receptor protein	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0876	0.3765
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.2327	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.2327	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0037	0.2327	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0037	0.2327	1
Echinococcus multilocularis	fmrfamide receptor	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Onchocerca volvulus		0.0037	0.2327	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Brugia malayi	hypothetical protein	0.0037	0.2327	1
Echinococcus granulosus	g protein coupled receptor	0.0037	0.2327	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.2327	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.2327	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0037	0.2327	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0037	0.2327	1
Onchocerca volvulus		0.0037	0.2327	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.2327	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.2327	1
Echinococcus multilocularis	serotonin receptor	0.0037	0.2327	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.2327	1
Onchocerca volvulus		0.0037	0.2327	1
Echinococcus granulosus	somatostatin receptor	0.0037	0.2327	1
Echinococcus multilocularis	orexin receptor type 2	0.0037	0.2327	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0037	0.2327	1
Echinococcus granulosus	G protein coupled receptor 139	0.0037	0.2327	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Onchocerca volvulus		0.0037	0.2327	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.2327	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0037	0.2327	1
Onchocerca volvulus		0.0037	0.2327	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0037	0.2327	1
Brugia malayi	Dopamine receptor protein 1	0.0037	0.2327	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0037	0.2327	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0037	0.2327	1
Schistosoma mansoni	hypothetical protein	0.0037	0.2327	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0037	0.2327	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0037	0.2327	1
Echinococcus multilocularis	neuropeptide receptor	0.0037	0.2327	1
Echinococcus multilocularis	g-protein coupled receptor	0.0037	0.2327	1
Schistosoma mansoni	amine GPCR	0.0037	0.2327	1
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.2327	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0037	0.2327	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0037	0.2327	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0037	0.2327	1
Schistosoma mansoni	opsin-like receptor	0.0037	0.2327	1
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0029	0.1655	0.5
Schistosoma mansoni	adenoreceptor	0.0037	0.2327	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.2327	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0037	0.2327	1
Brugia malayi	AKH receptor	0.0037	0.2327	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Schistosoma mansoni	biogenic amine receptor	0.0037	0.2327	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.2327	1
Leishmania major	mitochondrial DNA topoisomerase II	0.0073	0.5404	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0037	0.2327	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0037	0.2327	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0037	0.2327	1
Brugia malayi	hypothetical protein	0.0037	0.2327	1
Loa Loa (eye worm)	TOPoisomerase family member	0.0029	0.1655	0.7111
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0126	1	0.5
Schistosoma mansoni	hypothetical protein	0.0037	0.2327	1
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0073	0.5404	1
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0029	0.1655	0.7111
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.0126	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0037	0.2327	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0037	0.2327	1
Plasmodium vivax	DNA gyrase subunit B, putative	0.0126	1	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Schistosoma mansoni	biogenic amine receptor	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Mycobacterium ulcerans	DNA gyrase subunit B	0.0126	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Echinococcus multilocularis	sex peptide receptor	0.0037	0.2327	1
Onchocerca volvulus		0.0037	0.2327	1
Brugia malayi	G-protein coupled receptor	0.0037	0.2327	1
Brugia malayi	Melatonin receptor type 1A	0.0037	0.2327	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0037	0.2327	1
Echinococcus granulosus	g protein coupled receptor	0.0037	0.2327	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0037	0.2327	1
Echinococcus granulosus	neuropeptides capa receptor	0.0037	0.2327	1
Onchocerca volvulus		0.0037	0.2327	1
Schistosoma mansoni	amine GPCR	0.0037	0.2327	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Echinococcus granulosus	neuropeptide receptor A26	0.0037	0.2327	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.2327	1
Schistosoma mansoni	amine GPCR	0.0037	0.2327	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0037	0.2327	1
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.0126	1	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0037	0.2327	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0029	0.1655	0.7111
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.2327	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1
Entamoeba histolytica	DNA topoisomerase II, putative	0.0029	0.1655	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.2327	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0037	0.2327	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.2327	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 231 uM	In vitro inhibitory activity of the compound against human classical complement pathway	ChEMBL.	3155799
IC50 (functional)	= 231 uM	In vitro inhibitory activity of the compound against human classical complement pathway	ChEMBL.	3155799

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 13409293

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 61596