Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Drosophila melanogaster | NMDA receptor 2 | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 878 aa | 27.4 % |
Drosophila melanogaster | Glutamate receptor IA | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 979 aa | 23.7 % |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 822 aa | 23.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0035 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0127 | 1 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0109 | 0.8007 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.01 | 0.7036 | 0.7036 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.01 | 0.7036 | 0.7036 |
Brugia malayi | Protein kinase domain containing protein | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0095 | 0.6537 | 0.6537 |
Brugia malayi | Kringle domain containing protein | 0.0035 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.6537 | 0.6537 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Animals protected (functional) | = 1 | In vivo activity in DBA/2 Mouse audiogenic seizure model was determined by testing number of animals protected after a dose of 100 mg/Kg i.p.; Number of animals tested 8 mice | ChEMBL. | No reference |
Animals protected (functional) | = 1 | In vivo activity in DBA/2 Mouse audiogenic seizure model was determined by testing number of animals protected after a dose of 100 mg/Kg i.p.; Number of animals tested 8 mice | ChEMBL. | No reference |
IC50 (binding) | = 0.027 uM | Inhibition of [3H]-L-689,560 binding to Glycine site of NMDA receptor of rat cortical membranes | ChEMBL. | No reference |
IC50 (binding) | = 0.027 uM | Inhibition of [3H]-L-689,560 binding to Glycine site of NMDA receptor of rat cortical membranes | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.