Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.015 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.015 | 1 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0107 | 0.4452 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0107 | 0.4452 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.015 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0107 | 0.4452 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0107 | 0.4452 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.015 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0107 | 0.4452 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0107 | 0.4452 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0107 | 0.4452 | 1 |
Onchocerca volvulus | 0.0107 | 0.4452 | 1 | |
Echinococcus granulosus | thymidylate synthase | 0.0107 | 0.4452 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.015 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Clonic seizures (functional) | 0 | Compound was tested for its potential to produce clonic seizures in rats; + indicates compound is causing seizures | ChEMBL. | 2875184 |
MED (functional) | = 30 mg kg-1 | Ability to inhibit locomotor activity using ataxia test. | ChEMBL. | 2875184 |
MED (functional) | = 30 mg kg-1 | Ability to inhibit locomotor activity using ataxia test. | ChEMBL. | 2875184 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.