Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | histone deacetylase 2, putative | 0.011 | 0.1356 | 0.2063 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0599 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0304 | 0.4788 | 1 |
Trypanosoma brucei | histone deacetylase, putative | 0.011 | 0.1356 | 0.2063 |
Toxoplasma gondii | hypothetical protein | 0.0599 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.087 | 0.087 |
Echinococcus granulosus | histone deacetylase 7 | 0.011 | 0.1356 | 0.1241 |
Echinococcus granulosus | histone deacetylase 3 | 0.0216 | 0.3226 | 0.6013 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0304 | 0.4788 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0216 | 0.3226 | 0.6013 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0216 | 0.3226 | 0.5 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0116 | 0.1463 | 0.1513 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0304 | 0.4788 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0216 | 0.3226 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.011 | 0.1356 | 0.1241 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0216 | 0.3226 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0216 | 0.3226 | 0.2581 |
Loa Loa (eye worm) | histone deacetylase | 0.011 | 0.1356 | 0.1356 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.011 | 0.1356 | 0.1356 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0216 | 0.3226 | 0.6013 |
Loa Loa (eye worm) | hypothetical protein | 0.0599 | 1 | 1 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0216 | 0.3226 | 0.6013 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0216 | 0.3226 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0216 | 0.3226 | 1 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0083 | 0.087 | 0.5 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0216 | 0.3226 | 0.6013 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.011 | 0.1356 | 0.1241 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0216 | 0.3226 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0304 | 0.4788 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0216 | 0.3226 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0216 | 0.3226 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0304 | 0.4788 | 1 |
Echinococcus granulosus | histone deacetylase 1 | 0.0216 | 0.3226 | 0.6013 |
Echinococcus granulosus | histone deacetylase 6 | 0.011 | 0.1356 | 0.1241 |
Echinococcus multilocularis | histone deacetylase 6 | 0.011 | 0.1356 | 0.1241 |
Brugia malayi | Histone deacetylase 1 | 0.0216 | 0.3226 | 0.6013 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0083 | 0.087 | 0.087 |
Echinococcus multilocularis | histone deacetylase 7 | 0.011 | 0.1356 | 0.1241 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.011 | 0.1356 | 0.0533 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0304 | 0.4788 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.0216 | 0.3226 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.011 | 0.1356 | 0.1241 |
Echinococcus multilocularis | histone deacetylase | 0.011 | 0.1356 | 0.1241 |
Trypanosoma brucei | histone deacetylase 1 | 0.0216 | 0.3226 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.011 | 0.1356 | 0.2063 |
Plasmodium vivax | histone deacetylase, putative | 0.011 | 0.1356 | 0.2063 |
Brugia malayi | Histone deacetylase family protein | 0.011 | 0.1356 | 0.1241 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0116 | 0.1463 | 0.1513 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0216 | 0.3226 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.3226 | 0.3226 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.4788 | 0.4788 |
Echinococcus granulosus | histone deacetylase 6 | 0.0116 | 0.1463 | 0.1513 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.011 | 0.1356 | 0.1241 |
Leishmania major | histone deacetylase, putative | 0.0216 | 0.3226 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0599 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 4 | 0.011 | 0.1356 | 0.2063 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0216 | 0.3226 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0216 | 0.3226 | 0.3226 |
Plasmodium falciparum | histone deacetylase 1 | 0.0216 | 0.3226 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0216 | 0.3226 | 0.3226 |
Schistosoma mansoni | histone deacetylase | 0.0216 | 0.3226 | 0.6013 |
Trypanosoma brucei | histone deacetylase 3 | 0.011 | 0.1356 | 0.2063 |
Echinococcus multilocularis | histone deacetylase 6 | 0.011 | 0.1356 | 0.1241 |
Schistosoma mansoni | histone deacetylase | 0.0216 | 0.3226 | 0.6013 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0216 | 0.3226 | 0.5 |
Echinococcus granulosus | histone deacetylase | 0.011 | 0.1356 | 0.1241 |
Trypanosoma cruzi | histone deacetylase, putative | 0.011 | 0.1356 | 0.2063 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0216 | 0.3226 | 0.2581 |
Giardia lamblia | Histone deacetylase | 0.0216 | 0.3226 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0216 | 0.3226 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0291 | 0.4553 | 0.94 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0216 | 0.3226 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.011 | 0.1356 | 0.2063 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.8 uM | In vitro Schultz-Dale Test against isolated guinea pig lung strips repeatedly challenged with antigen in the presence of an antihistamine (H1) at a concentration 30 uM. | ChEMBL. | 6150113 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.