TDR Targets

Basic information

Technical information

TDR Targets ID: 622201
Name: [1-[(4-fluorophenoxy)methyl]-6,7-dimethoxy-3, 4-dihydro-1H-isoquinolin-2-yl]-(3-nitrophenyl )methanone
MW: 466.458 | Formula: C25H23FN2O6
H donors: 0 H acceptors: 3 LogP: 4.48 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2CCN(C(c2cc1OC)COc1ccc(cc1)F)C(=O)c1cccc(c1)[N+](=O)[O-]
InChi: 1S/C25H23FN2O6/c1-32-23-13-16-10-11-27(25(29)17-4-3-5-19(12-17)28(30)31)22(21(16)14-24(23)33-2)15-34-20-8-6-18(26)7-9-20/h3-9,12-14,22H,10-11,15H2,1-2H3
InChiKey: NTFHOMHYOIAFSP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

Oprea1_814905

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Schistosoma mansoni	neuropeptide receptor	0.0054	0.1519	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Brugia malayi	hypothetical protein	0.0054	0.1519	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0054	0.1519	0.1283
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0054	0.1519	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0054	0.1519	0.1283
Echinococcus granulosus	dro:myosuppressin receptor	0.0054	0.1519	0.1283
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.002	0.0271	0.5
Brugia malayi	AKH receptor	0.0054	0.1519	1
Onchocerca volvulus		0.0054	0.1519	0.5
Brugia malayi	hypothetical protein	0.0054	0.1519	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Echinococcus multilocularis	g-protein coupled receptor	0.0054	0.1519	0.1283
Brugia malayi	putative neuropeptide receptor	0.0054	0.1519	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Echinococcus granulosus	g-protein coupled receptor	0.0054	0.1519	0.1283
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Echinococcus multilocularis	g protein coupled receptor	0.0054	0.1519	0.1283
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.1519	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0054	0.1519	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0054	0.1519	1
Schistosoma mansoni	hypothetical protein	0.0054	0.1519	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0054	0.1519	0.1283
Echinococcus multilocularis	g protein coupled receptor	0.0054	0.1519	0.1283
Loa Loa (eye worm)	G-protein coupled receptor	0.0054	0.1519	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0054	0.1519	0.1283
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0054	0.1519	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.002	0.0271	1
Brugia malayi	Dopamine receptor protein 2	0.0054	0.1519	1
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0288	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0054	0.1519	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0054	0.1519	0.1283
Trypanosoma cruzi	hypothetical protein, conserved	0.0101	0.32	1
Echinococcus granulosus	neuropeptide s receptor	0.0054	0.1519	0.1283
Giardia lamblia	GTOR	0.002	0.0271	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Echinococcus multilocularis	neuropeptide s receptor	0.0054	0.1519	0.1283
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Schistosoma mansoni	histamine h1 receptor	0.0054	0.1519	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0054	0.1519	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.1519	1
Schistosoma mansoni	neuropeptide receptor	0.0054	0.1519	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0054	0.1519	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0054	0.1519	1
Brugia malayi	hypothetical protein	0.0054	0.1519	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.1519	0.1283
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.1519	0.1283
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Toxoplasma gondii	target of rapamycin (TOR), putative	0.002	0.0271	1
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.002	0.0271	1
Brugia malayi	Serotonin receptor	0.0054	0.1519	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.1519	0.1283
Loa Loa (eye worm)	neuropeptide F receptor	0.0054	0.1519	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.1519	0.1283
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0054	0.1519	1
Schistosoma mansoni	amine GPCR	0.0054	0.1519	1
Schistosoma mansoni	amine GPCR	0.0054	0.1519	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0054	0.1519	0.1283
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.1519	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0054	0.1519	0.1283
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.1519	0.1283
Echinococcus granulosus	g protein coupled receptor	0.0054	0.1519	0.1283
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0054	0.1519	1
Echinococcus granulosus	neuropeptide Y receptor	0.0054	0.1519	0.1283
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Brugia malayi	G-protein coupled receptor	0.0054	0.1519	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Brugia malayi	ORL1-like opioid receptor	0.0054	0.1519	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.1519	0.1283
Brugia malayi	RE15519p	0.0054	0.1519	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0054	0.1519	0.1283
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Onchocerca volvulus		0.0054	0.1519	0.5
Echinococcus multilocularis	dro:myosuppressin receptor	0.0054	0.1519	0.1283
Schistosoma mansoni	hypothetical protein	0.0054	0.1519	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Onchocerca volvulus		0.0054	0.1519	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0054	0.1519	0.1283
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0054	0.1519	0.1283
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0054	0.1519	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0054	0.1519	0.1283
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0054	0.1519	0.1283
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0054	0.1519	0.1283
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Echinococcus granulosus	sex peptide receptor	0.0054	0.1519	0.1283
Schistosoma mansoni	biogenic amine receptor	0.0054	0.1519	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0054	0.1519	0.1283
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.1519	1
Onchocerca volvulus		0.0054	0.1519	0.5
Onchocerca volvulus		0.0054	0.1519	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.1519	0.1283
Echinococcus multilocularis	g protein coupled receptor	0.0054	0.1519	0.1283
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Echinococcus granulosus	hypothetical protein	0.0054	0.1519	0.1283
Echinococcus granulosus	g protein coupled receptor	0.0054	0.1519	0.1283
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0054	0.1519	0.1283
Echinococcus granulosus	neuropeptides capa receptor	0.0054	0.1519	0.1283
Brugia malayi	neuropeptide F receptor	0.0054	0.1519	1
Brugia malayi	Melatonin receptor type 1A	0.0054	0.1519	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0054	0.1519	0.1283
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.002	0.0271	1
Echinococcus granulosus	neuropeptide receptor	0.0054	0.1519	0.1283
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Schistosoma mansoni	amine GPCR	0.0054	0.1519	1
Brugia malayi	hypothetical protein	0.0054	0.1519	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Schistosoma mansoni	biogenic amine receptor	0.0054	0.1519	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0054	0.1519	1
Brugia malayi	hypothetical protein	0.0054	0.1519	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Brugia malayi	Dopamine receptor protein 1	0.0054	0.1519	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Brugia malayi	GnHR receptor homolog	0.0054	0.1519	1
Loa Loa (eye worm)	TYRA-2 protein	0.0054	0.1519	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0054	0.1519	0.1283
Onchocerca volvulus		0.0054	0.1519	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0054	0.1519	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0054	0.1519	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0054	0.1519	0.1283
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0054	0.1519	1
Schistosoma mansoni	biogenic amine receptor	0.0054	0.1519	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0054	0.1519	0.1283
Echinococcus multilocularis	neuropeptide receptor	0.0054	0.1519	0.1283
Echinococcus multilocularis	fmrfamide receptor	0.0054	0.1519	0.1283
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Onchocerca volvulus		0.0054	0.1519	0.5
Brugia malayi	sulfakinin receptor protein	0.0054	0.1519	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Echinococcus multilocularis	fmrfamide receptor	0.0054	0.1519	0.1283
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Onchocerca volvulus		0.0054	0.1519	0.5
Onchocerca volvulus		0.0054	0.1519	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0054	0.1519	1
Brugia malayi	larval opioid receptor	0.0054	0.1519	1
Echinococcus granulosus	G protein coupled receptor 139	0.0054	0.1519	0.1283
Echinococcus granulosus	allatostatin A receptor	0.0054	0.1519	0.1283
Echinococcus multilocularis	allatostatin A receptor	0.0054	0.1519	0.1283
Echinococcus multilocularis	neuropeptides capa receptor	0.0054	0.1519	0.1283
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0054	0.1519	0.1283
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0054	0.1519	1
Echinococcus granulosus	neuropeptides capa receptor	0.0054	0.1519	0.1283
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Schistosoma mansoni	adenoreceptor	0.0054	0.1519	1
Brugia malayi	hypothetical protein	0.0054	0.1519	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Onchocerca volvulus		0.0054	0.1519	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0054	0.1519	0.1283
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0054	0.1519	0.1283
Schistosoma mansoni	hypothetical protein	0.0054	0.1519	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.1519	0.1283
Echinococcus granulosus	g protein coupled receptor	0.0054	0.1519	0.1283
Brugia malayi	G protein-coupled receptor	0.0054	0.1519	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Brugia malayi	neuropeptide F receptor	0.0054	0.1519	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0054	0.1519	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Brugia malayi	hypothetical protein	0.0054	0.1519	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0054	0.1519	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.1519	0.1283
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Echinococcus multilocularis	orexin receptor type 2	0.0054	0.1519	0.1283
Echinococcus granulosus	neuropeptide Y receptor	0.0054	0.1519	0.1283
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0054	0.1519	0.1283
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.1519	0.1283
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0054	0.1519	0.1283
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.002	0.0271	0.5
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0054	0.1519	0.5
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.002	0.0271	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0054	0.1519	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.1519	0.1283
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.1519	1
Echinococcus granulosus	orexin receptor type 2	0.0054	0.1519	0.1283
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0054	0.1519	0.1283
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.1519	0.1283
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0054	0.1519	0.1283
Loa Loa (eye worm)	phosphatidylinositol 3	0.002	0.0271	0.1783
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Brugia malayi	hypothetical protein	0.0054	0.1519	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0054	0.1519	0.1283
Echinococcus multilocularis	neuropeptide receptor	0.0054	0.1519	0.1283
Onchocerca volvulus		0.0054	0.1519	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0054	0.1519	0.1283
Onchocerca volvulus		0.0054	0.1519	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0054	0.1519	0.1283
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0054	0.1519	1
Onchocerca volvulus		0.0054	0.1519	0.5
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0054	0.1519	1
Schistosoma mansoni	opsin-like receptor	0.0054	0.1519	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0054	0.1519	0.1283
Loa Loa (eye worm)	G-protein coupled receptor	0.0054	0.1519	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0054	0.1519	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0054	0.1519	0.1283
Echinococcus multilocularis	serotonin receptor	0.0054	0.1519	0.1283
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0054	0.1519	1
Schistosoma mansoni	neuropeptide receptor	0.0054	0.1519	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0054	0.1519	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0054	0.1519	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0054	0.1519	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0054	0.1519	1
Echinococcus granulosus	neuropeptide receptor	0.0054	0.1519	0.1283
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0054	0.1519	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0054	0.1519	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0054	0.1519	0.1283
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Schistosoma mansoni	neuropeptide receptor	0.0054	0.1519	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0054	0.1519	1
Brugia malayi	Serotonin receptor	0.0054	0.1519	1
Echinococcus multilocularis	sex peptide receptor	0.0054	0.1519	0.1283
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Brugia malayi	hypothetical protein	0.0054	0.1519	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0054	0.1519	0.1283
Schistosoma mansoni	neuropeptide F-like receptor	0.0054	0.1519	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0054	0.1519	0.1283
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0054	0.1519	1
Echinococcus multilocularis	somatostatin receptor	0.0054	0.1519	0.1283
Brugia malayi	hypothetical protein	0.0054	0.1519	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Echinococcus granulosus	somatostatin receptor	0.0054	0.1519	0.1283
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0054	0.1519	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Schistosoma mansoni	opsin-like receptor	0.0054	0.1519	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.1519	1
Onchocerca volvulus		0.0054	0.1519	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Leishmania major	hypothetical protein, conserved	0.0105	0.334	1
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.002	0.0271	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.1519	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.1519	0.1283
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.1519	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.1519	1
Echinococcus granulosus	neuropeptide receptor A26	0.0054	0.1519	0.1283
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Echinococcus granulosus	fmrfamide receptor	0.0054	0.1519	0.1283
Schistosoma mansoni	amine GPCR	0.0054	0.1519	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.1519	0.1283
Brugia malayi	follicle stimulating hormone receptor	0.0054	0.1519	1
Onchocerca volvulus		0.0054	0.1519	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Schistosoma mansoni	hypothetical protein	0.0054	0.1519	1
Schistosoma mansoni	myosin xvIII	0.0054	0.1519	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0054	0.1519	0.1283
Schistosoma mansoni	amine GPCR	0.0054	0.1519	1
Onchocerca volvulus		0.0054	0.1519	0.5
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0054	0.1519	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.1519	0.1283
Onchocerca volvulus		0.0054	0.1519	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.002	0.0271	0.1783
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0054	0.1519	0.1283
Brugia malayi	G-protein coupled receptor	0.0054	0.1519	1
Brugia malayi	Dopamine receptor	0.0054	0.1519	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0054	0.1519	0.1283
Brugia malayi	G protein-coupled receptor F59B2.13	0.0054	0.1519	1
Echinococcus multilocularis	serotonin receptor	0.0054	0.1519	0.1283
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0054	0.1519	0.1283
Schistosoma mansoni	opsin-like receptor	0.0054	0.1519	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1519	1
Echinococcus granulosus	serotonin receptor	0.0054	0.1519	0.1283

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 622201