Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.8951 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.4088 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.8951 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0164 | 0.3761 | 1 |
Plasmodium vivax | RNA helicase-1, putative | 0.0171 | 0.4088 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0171 | 0.4088 | 0.4088 |
Mycobacterium ulcerans | hypothetical protein | 0.0164 | 0.3761 | 1 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0171 | 0.4088 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 0.0306 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 0.0306 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.8951 | 1 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0171 | 0.4088 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0282 | 0.8951 | 1 |
Schistosoma mansoni | inositol transporter | 0.0306 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.8951 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.8951 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0171 | 0.4088 | 0.4088 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0171 | 0.4088 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0171 | 0.4088 | 0.5 |
Echinococcus granulosus | solute carrier family 5 | 0.0306 | 1 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0171 | 0.4088 | 0.4088 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0171 | 0.4088 | 0.5 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0306 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0164 | 0.3761 | 0.7772 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.8951 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.8951 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0171 | 0.4088 | 0.063 |
Mycobacterium tuberculosis | Conserved protein | 0.0164 | 0.3761 | 0.7772 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0282 | 0.8951 | 1 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0171 | 0.4088 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0164 | 0.3761 | 1 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0306 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0171 | 0.4088 | 0.4088 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0171 | 0.4088 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0171 | 0.4088 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0306 | 1 | 1 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0306 | 1 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0171 | 0.4088 | 0.4088 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0171 | 0.4088 | 0.4088 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0171 | 0.4088 | 0.5 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0282 | 0.8951 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0282 | 0.8951 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 0.8951 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0171 | 0.4088 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 58 % | Antagonistic blocking activity at alpha adrenergic receptor by NE induced contractions of the epididymal portion of isolated rat vas deferens at the dose of 20 microM | ChEMBL. | 2999398 |
Activity (functional) | = 58 % | Antagonistic blocking activity at alpha adrenergic receptor by NE induced contractions of the epididymal portion of isolated rat vas deferens at the dose of 20 microM | ChEMBL. | 2999398 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.