Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0331 | 0.0331 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0323 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0167 | 0.4794 | 0.4616 |
Mycobacterium ulcerans | thymidylate synthase | 0.0323 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0154 | 0.4357 | 0.4164 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0323 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0331 | 0.0233 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.4794 | 0.4616 |
Chlamydia trachomatis | pyruvate kinase | 0.0033 | 0.0331 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0331 | 0.0331 |
Echinococcus granulosus | thymidylate synthase | 0.0323 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0154 | 0.4357 | 0.4164 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0323 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0167 | 0.4794 | 0.4741 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0323 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.4794 | 0.4616 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0323 | 1 | 1 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0323 | 1 | 1 |
Onchocerca volvulus | 0.0323 | 1 | 1 | |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0323 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0323 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0154 | 0.4357 | 0.4164 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0323 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0331 | 0.0331 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0331 | 0.0331 |
Echinococcus multilocularis | thymidylate synthase | 0.0323 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0331 | 0.0233 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0154 | 0.4357 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0323 | 1 | 1 |
Giardia lamblia | Pyruvate kinase | 0.0033 | 0.0331 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.