Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.1126 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.1126 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.2788 | 0.2486 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0607 | 0.0607 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1126 | 0.0552 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0607 | 0.5 |
Echinococcus multilocularis | Eukaryotic translation initiation factor 4H | 0.0139 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.2788 | 0.2788 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0607 | 0.0607 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.1126 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0607 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0607 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0607 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0607 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0607 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.1126 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2788 | 0.2788 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2788 | 0.2788 |
Brugia malayi | hypothetical protein | 0.0026 | 0.1126 | 0.0754 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.2788 | 0.2788 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0607 | 0.0607 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0607 | 0.0214 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0607 | 0.0607 |
Schistosoma mansoni | eukaryotic translation initiation factor 4h | 0.0139 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.1126 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.1126 | 1 |
Schistosoma mansoni | eukaryotic translation initiation factor 4h | 0.0139 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0607 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.1126 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2788 | 0.2788 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.2788 | 0.2322 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.2788 | 0.2788 |
Echinococcus granulosus | Eukaryotic translation initiation factor 4H | 0.0139 | 1 | 1 |
Schistosoma mansoni | eukaryotic translation initiation factor 4h | 0.0139 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.1126 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0607 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.2788 | 0.2788 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.