Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.4147 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0206 | 0.9203 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.4147 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0095 | 0.3513 | 0.8471 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0095 | 0.3513 | 0.8471 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0222 | 1 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0107 | 0.4147 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0095 | 0.3513 | 0.8471 |
Echinococcus granulosus | acetylcholinesterase | 0.0095 | 0.3513 | 0.8471 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0095 | 0.3513 | 0.8471 |
Echinococcus granulosus | acetylcholinesterase | 0.0095 | 0.3513 | 0.8471 |
Brugia malayi | Muscleblind-like protein | 0.0107 | 0.4147 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0095 | 0.3513 | 0.8471 |
Echinococcus granulosus | carboxylesterase 5A | 0.0095 | 0.3513 | 0.8471 |
Echinococcus multilocularis | muscleblind protein | 0.0107 | 0.4147 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0095 | 0.3513 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0107 | 0.4147 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.