Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | pyruvate kinase, putative | 0.0117 | 1 | 1 |
Giardia lamblia | Pyruvate kinase | 0.0117 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0117 | 1 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0117 | 1 | 0.5 |
Schistosoma mansoni | pyruvate kinase | 0.0117 | 1 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.0117 | 1 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0117 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0117 | 1 | 0.5 |
Schistosoma mansoni | pyruvate kinase | 0.0117 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0117 | 1 | 1 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0117 | 1 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.0117 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0117 | 1 | 0.5 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0117 | 1 | 0.5 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0117 | 1 | 0.5 |
Leishmania major | pyruvate kinase | 0.0117 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 1 | 1 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0081 | 0.5661 | 0.5 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0117 | 1 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0117 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0117 | 1 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.0117 | 1 | 1 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0117 | 1 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0117 | 1 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.0117 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0117 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0117 | 1 | 0.5 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0117 | 1 | 1 |
Leishmania major | pyruvate kinase | 0.0117 | 1 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0117 | 1 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0092 | 0.6979 | 0.5671 |
Echinococcus multilocularis | pyruvate kinase | 0.0117 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10.2 uM | In vitro inhibitory activity against human prostaglandin G/H synthase 2 | ChEMBL. | 9171872 |
IC50 (binding) | = 10.2 uM | In vitro inhibitory activity against human prostaglandin G/H synthase 2 | ChEMBL. | 9171872 |
IC50 (binding) | > 100 uM | In vitro inhibitory activity against human prostaglandin G/H synthase 1 | ChEMBL. | 9171872 |
IC50 (binding) | > 100 uM | In vitro inhibitory activity against human prostaglandin G/H synthase 1 | ChEMBL. | 9171872 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.