Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cytochrome p450-like protein | 0.00375727 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.01004 | 0.183541 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.01004 | 0.183541 | 1 |
Plasmodium falciparum | beta-hydroxyacyl-ACP dehydratase | 0.0357722 | 0.935268 | 0.5 |
Toxoplasma gondii | 1,3-beta-glucan synthase component protein | 0.0379881 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.00375727 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.00375727 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | (3R)-hydroxymyristoyl-ACP dehydratase | 0.0357722 | 0.935268 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.00375727 | 0 | 0.5 |
Plasmodium vivax | beta-hydroxyacyl-ACP dehydratase precursor, putative | 0.0357722 | 0.935268 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.00375727 | 0 | 0.5 |
Chlamydia trachomatis | 3-hydroxyacyl-ACP dehydratase | 0.0357722 | 0.935268 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cytotoxicity (functional) | = 0 % | Cytotoxicity against MRC-5 cells at concentration 1 microM | ChEMBL. | 11356101 |
Cytotoxicity (functional) | = 0 % | Cytotoxicity against MRC-5 cells at concentration 0.5 microM | ChEMBL. | 11356101 |
Cytotoxicity (ADMET) | 0 % | In vitro cytotoxic activity against mouse peritonealmacrophages at a concentration 32 microM; Toxic | ChEMBL. | 11356101 |
Cytotoxicity (ADMET) | 0 % | In vitro cytotoxic activity against mouse peritonealmacrophages at a concentration 8 microM; Toxic | ChEMBL. | 11356101 |
Cytotoxicity (functional) | 0 % | In vitro cytotoxic activity against mouse peritoneal macrophages at a concentration 2 microM; Non-toxic | ChEMBL. | 11356101 |
Cytotoxicity (functional) | = 0 % | Cytotoxicity against MRC-5 cells at concentration 1 microM | ChEMBL. | 11356101 |
Cytotoxicity (functional) | = 0 % | Cytotoxicity against MRC-5 cells at concentration 0.5 microM | ChEMBL. | 11356101 |
Cytotoxicity (functional) | = 87 % | Cytotoxicity against MRC-5 cells at concentration 8 microM | ChEMBL. | 11356101 |
Cytotoxicity (functional) | = 87 % | Cytotoxicity against MRC-5 cells at concentration 8 microM | ChEMBL. | 11356101 |
Cytotoxicity (functional) | = 91 % | Cytotoxicity against MRC-5 cells at concentration 32 microM | ChEMBL. | 11356101 |
Cytotoxicity (functional) | = 91 % | Cytotoxicity against MRC-5 cells at concentration 32 microM | ChEMBL. | 11356101 |
IC50 (functional) | = 16.1 nM | In vitro growth inhibition of P. falciparum F32 strain | ChEMBL. | 11356101 |
IC50 (functional) | = 16.1 nM | In vitro growth inhibition of P. falciparum F32 strain | ChEMBL. | 11356101 |
IC50 (functional) | = 18.9 nM | In vitro growth inhibition of P. falciparum D6 strain | ChEMBL. | 11356101 |
IC50 (functional) | = 18.9 nM | In vitro growth inhibition of P. falciparum D6 strain | ChEMBL. | 11356101 |
IC50 (functional) | = 38.6 nM | In vitro growth inhibition of P. falciparum FcB1R strain. | ChEMBL. | 11356101 |
IC50 (functional) | = 38.6 nM | In vitro growth inhibition of P. falciparum FcB1R strain. | ChEMBL. | 11356101 |
IC50 (functional) | = 50.2 nM | In vitro growth inhibition of P. falciparum W2 strain | ChEMBL. | 11356101 |
IC50 (functional) | = 50.2 nM | In vitro growth inhibition of P. falciparum W2 strain | ChEMBL. | 11356101 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 11356101 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.