Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin E receptor 4 (subtype EP4) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | voltage dependent calcium channel | 0.0101 | 0.1633 | 0.1309 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0118 | 0.2313 | 0.2255 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0101 | 0.1633 | 0.1309 |
Mycobacterium ulcerans | adenylylate/guanylate cyclase | 0.0166 | 0.4292 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0118 | 0.2313 | 0.2255 |
Echinococcus multilocularis | integrin beta 2 | 0.0225 | 0.6751 | 0.8431 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0101 | 0.1633 | 0.1309 |
Schistosoma mansoni | integrin beta subunit | 0.0179 | 0.4846 | 0.578 |
Loa Loa (eye worm) | calcium channel | 0.0101 | 0.1633 | 0.101 |
Onchocerca volvulus | Atrial natriuretic peptide receptor 3 homolog | 0.0252 | 0.7878 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0118 | 0.2313 | 0.1741 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0101 | 0.1633 | 0.1309 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0101 | 0.1633 | 0.1309 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.2313 | 0.1741 |
Schistosoma mansoni | protein kinase | 0.0252 | 0.7878 | 1 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0252 | 0.7878 | 0.772 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0101 | 0.1633 | 0.1309 |
Leishmania major | extracellular receptor, putative | 0.0078 | 0.0692 | 0.5 |
Echinococcus multilocularis | receptor type guanylyl cyclase | 0.0252 | 0.7878 | 1 |
Schistosoma mansoni | neuropeptide receptor | 0.0183 | 0.5012 | 0.6011 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0118 | 0.2313 | 0.2255 |
Echinococcus granulosus | integrin beta 2 | 0.0225 | 0.6751 | 0.8431 |
Echinococcus granulosus | neuropeptide receptor | 0.0183 | 0.5012 | 0.6011 |
Schistosoma mansoni | voltage-gated cation channel | 0.0101 | 0.1633 | 0.1309 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0.0692 | 0.5 |
Onchocerca volvulus | 0.0107 | 0.1893 | 0.1672 | |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0118 | 0.2313 | 0.2255 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0252 | 0.7878 | 0.772 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0101 | 0.1633 | 0.101 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.2313 | 0.1741 |
Onchocerca volvulus | 0.0118 | 0.2313 | 0.2255 | |
Echinococcus granulosus | receptor type guanylyl cyclase | 0.0252 | 0.7878 | 1 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0101 | 0.1633 | 0.1309 |
Schistosoma mansoni | tyrosine kinase | 0.0087 | 0.1051 | 0.0499 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0118 | 0.2313 | 0.2255 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0118 | 0.2313 | 0.2255 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1388 | 0.0748 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0101 | 0.1633 | 0.1309 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.2313 | 0.1741 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0183 | 0.5012 | 0.6011 |
Onchocerca volvulus | 0.0118 | 0.2313 | 0.2255 | |
Schistosoma mansoni | tyrosine kinase | 0.0087 | 0.1051 | 0.0499 |
Onchocerca volvulus | Putative nachr subunit | 0.0118 | 0.2313 | 0.2255 |
Echinococcus multilocularis | atrial natriuretic peptide receptor | 0.0223 | 0.6677 | 0.8328 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0252 | 0.7878 | 0.772 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.1051 | 0.0385 |
Trypanosoma cruzi | extracellular receptor, putative | 0.0078 | 0.0692 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0101 | 0.1633 | 0.1309 |
Echinococcus granulosus | tyrosine kinase | 0.0087 | 0.1051 | 0.0499 |
Echinococcus multilocularis | neuropeptide receptor | 0.0183 | 0.5012 | 0.6011 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0118 | 0.2313 | 0.1741 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0101 | 0.1633 | 0.1309 |
Echinococcus granulosus | atrial natriuretic peptide receptor | 0.0223 | 0.6677 | 0.8328 |
Onchocerca volvulus | 0.0118 | 0.2313 | 0.2255 | |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0101 | 0.1633 | 0.1309 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0061 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1633 | 0.101 |
Brugia malayi | Guanylyl cyclase protein 23 | 0.0107 | 0.1893 | 0.129 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0118 | 0.2313 | 0.2255 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0101 | 0.1633 | 0.1309 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0118 | 0.2313 | 0.2255 |
Brugia malayi | Cation transporter family protein | 0.0118 | 0.2313 | 0.1741 |
Echinococcus multilocularis | tyrosine kinase | 0.0087 | 0.1051 | 0.0499 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0107 | 0.1893 | 0.129 |
Loa Loa (eye worm) | integrin beta-2 | 0.0304 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 10000 nM | Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells | ChEMBL. | 15026044 |
EC50 (functional) | > 10000 nM | Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cells | ChEMBL. | 15026044 |
Ki (binding) | nM | Binding affinity against prostanoid EP4 receptor; nd=Not determined | ChEMBL. | 15026044 |
Ki (binding) | nM | Binding affinity against prostanoid EP2 receptor; nd=Not determined | ChEMBL. | 15026044 |
Ki (binding) | nM | Binding affinity against prostanoid EP1 receptor; nd=Not determined | ChEMBL. | 15026044 |
Ki (binding) | nM | Binding affinity of the compound against prostanoid EP3 receptor; nd=Not determined | ChEMBL. | 15026044 |
Ki (binding) | 0 nM | Binding affinity against prostanoid EP1 receptor; nd=Not determined | ChEMBL. | 15026044 |
Ki (binding) | 0 nM | Binding affinity against prostanoid EP2 receptor; nd=Not determined | ChEMBL. | 15026044 |
Ki (binding) | 0 nM | Binding affinity of the compound against prostanoid EP3 receptor; nd=Not determined | ChEMBL. | 15026044 |
Ki (binding) | 0 nM | Binding affinity against prostanoid EP4 receptor; nd=Not determined | ChEMBL. | 15026044 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.