Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0025 | 0.4954 | 0.4954 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0035 | 1 | 1 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0035 | 1 | 1 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0035 | 1 | 1 |
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0035 | 1 | 1 |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0035 | 1 | 0.5 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0035 | 1 | 1 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0035 | 1 | 1 |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0035 | 1 | 0.5 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0035 | 1 | 1 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0035 | 1 | 1 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0035 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.