Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0183 | 0.3928 | 1 |
Onchocerca volvulus | 0.0102 | 0.0879 | 1 | |
Trypanosoma cruzi | GMP reductase | 0.0183 | 0.3928 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0102 | 0.0879 | 0.2238 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0183 | 0.3928 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0879 | 0.2238 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.01 | 0.0783 | 0.1633 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0102 | 0.0879 | 0.2238 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0179 | 0.3758 | 0.9548 |
Leishmania major | guanosine monophosphate reductase | 0.0183 | 0.3928 | 0.5 |
Onchocerca volvulus | 0.0102 | 0.0879 | 1 | |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0183 | 0.3928 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0183 | 0.3928 | 0.5 |
Onchocerca volvulus | 0.0102 | 0.0879 | 1 | |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0183 | 0.3928 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0183 | 0.3928 | 0.5 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0179 | 0.3758 | 0.5 |
Trypanosoma brucei | GMP reductase | 0.0183 | 0.3928 | 0.5 |
Onchocerca volvulus | 0.0102 | 0.0879 | 1 | |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0183 | 0.3928 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0183 | 0.3928 | 0.5 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0183 | 0.3928 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0183 | 0.3928 | 1 |
Toxoplasma gondii | IMP dehydrogenas | 0.0183 | 0.3928 | 0.5 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0179 | 0.3758 | 0.5 |
Onchocerca volvulus | 0.0102 | 0.0879 | 1 | |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0183 | 0.3928 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0345 | 1 | 1 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0183 | 0.3928 | 0.5 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0102 | 0.0879 | 0.2238 |
Onchocerca volvulus | 0.0102 | 0.0879 | 1 | |
Onchocerca volvulus | 0.0102 | 0.0879 | 1 | |
Onchocerca volvulus | 0.0102 | 0.0879 | 1 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0102 | 0.0879 | 0.2238 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0183 | 0.3928 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.