Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | steroid hormone receptor | 0.0012 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0006 | 0.1071 | 0.1071 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.1071 | 0.1071 |
Brugia malayi | hypothetical protein | 0.0006 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0006 | 0.1071 | 0.1071 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0006 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.1071 | 0.1071 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0006 | 0.1071 | 0.1071 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0006 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0006 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.1071 | 0.1071 |
Brugia malayi | nuclear receptor RXR | 0.0006 | 0.1071 | 0.1071 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.1071 | 0.1071 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 1 | 1 |
Onchocerca volvulus | 0.0012 | 1 | 1 | |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0006 | 0.1071 | 0.1071 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0006 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1827 uM | PUBCHEM_BIOASSAY: qHTS Assay for Compounds that Act as Agonists of the Vanilloid Receptor 1: Hit Validation. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.205 uM | PUBCHEM_BIOASSAY: qHTS Assay for Compounds that Act as Potentiators of the Vanilloid Receptor 1: Hit Validation. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.631 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 1.4716 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 2.5119 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 3.2944 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.