Detailed information for compound 65311

Basic information

Technical information
  • TDR Targets ID: 65311
  • Name: (5R)-8-{[(6S,2R,7R)-4-(2-Chloroprop-2-enyl)-6 -methoxy-7-methyl(1,4-oxazaperhydroepin-2-ylo xy)]methyl}-1-formyl-5-methyl-10-(methylethyl )tetracyclo[7.4.0.0<2,6>.0<8,12>]tridec-10-en e-9-carboxylic acid
  • MW: 550.126 | Formula: C30H44ClNO6
  • H donors: 1 H acceptors: 3 LogP: 1.56 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CO[C@H]1CN(C[C@@H](O[C@@H]1C)OCC12C[C@@H]3[C@H](C)CC[C@H]3C3(C2(C(=O)O)C(=CC1C3)C(C)C)C=O)CC(=C)Cl
  • InChi: 1S/C30H44ClNO6/c1-17(2)24-9-21-10-28(15-33)23-8-7-18(3)22(23)11-29(21,30(24,28)27(34)35)16-37-26-14-32(12-19(4)31)13-25(36-6)20(5)38-26/h9,15,17-18,20-23,25-26H,4,7-8,10-14,16H2,1-3,5-6H3,(H,34,35)/t18-,20-,21?,22-,23-,25+,26-,28?,29?,30?/m1/s1
  • InChiKey: VHLSXFISWXOQFA-HOMSESCUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • AIDS-155233
  • AIDS155233

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0211 1 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.3996 0.3996
Loa Loa (eye worm) hypothetical protein 0.0132 0.3996 0.3996
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0132 0.3996 0.3996
Echinococcus granulosus c src tyrosine kinase 0.0211 1 1
Echinococcus granulosus signal transduction protein lnk realted 0.0132 0.3996 0.3996
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0132 0.3996 0.3996
Leishmania major protein kinase, putative 0.0079 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0211 1 1
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0132 0.3996 0.3996
Loa Loa (eye worm) TK/FER protein kinase 0.0211 1 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0211 1 1
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Onchocerca volvulus 0.0132 0.3996 0.3996
Schistosoma mansoni growth factor receptor-bound protein 0.0132 0.3996 0.3996
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0211 1 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0132 0.3996 0.3996
Plasmodium falciparum tyrosine kinase-like protein 0.0079 0 0.5
Loa Loa (eye worm) TK/ABL protein kinase 0.0211 1 1
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Brugia malayi Variant SH3 domain containing protein 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0211 1 1
Leishmania major hypothetical protein, conserved 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0211 1 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0132 0.3996 0.3996
Echinococcus granulosus tyrosine protein kinase shark 0.0211 1 1
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0211 1 1
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0211 1 1
Echinococcus granulosus SH2 motif 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Schistosoma mansoni hypothetical protein 0.0132 0.3996 0.3996
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0132 0.3996 0.3996
Schistosoma mansoni tensin-related 0.0132 0.3996 0.3996
Echinococcus multilocularis tyrosine protein kinase Abl 0.0211 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0211 1 1
Schistosoma mansoni shc transforming protein 0.0132 0.3996 0.3996
Leishmania major protein kinase, putative 0.0079 0 0.5
Schistosoma mansoni suppressor of cytokine signaling 0.0132 0.3996 0.3996
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0132 0.3996 0.3996
Schistosoma mansoni tyrosine kinase 0.0211 1 1
Trypanosoma cruzi protein kinase, putative 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Onchocerca volvulus 0.0211 1 1
Brugia malayi SH2 domain containing protein 0.0132 0.3996 0.3996
Trichomonas vaginalis protein kinase atn1, putative 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0132 0.3996 0.3996
Brugia malayi Tyrosine-protein kinase abl-1 0.0211 1 1
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Schistosoma mansoni tensin-related 0.0132 0.3996 0.3996
Schistosoma mansoni tyrosine kinase 0.0211 1 1
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0079 0 0.5
Echinococcus multilocularis tyrosine protein kinase shark 0.0211 1 1
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0079 0 0.5
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0132 0.3996 0.3996
Onchocerca volvulus 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Brugia malayi Variant SH3 domain containing protein 0.0132 0.3996 0.3996
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0079 0 0.5
Plasmodium falciparum tyrosine kinase-like protein 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Echinococcus granulosus tyrosine protein kinase Src64B 0.0211 1 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0211 1 1
Giardia lamblia Kinase, NEK 0.0079 0 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.0079 0 0.5
Plasmodium vivax protein kinase, putative 0.0079 0 0.5
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0079 0 0.5
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0211 1 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0132 0.3996 0.3996
Loa Loa (eye worm) hypothetical protein 0.0132 0.3996 0.3996
Loa Loa (eye worm) hypothetical protein 0.0132 0.3996 0.3996
Echinococcus granulosus tyrosine protein kinase Src42A 0.0132 0.3996 0.3996
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0132 0.3996 0.3996
Brugia malayi SH2 domain containing protein 0.0211 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0079 0 0.5
Schistosoma mansoni tensin 0.0132 0.3996 0.3996
Schistosoma mansoni SH2A 0.0132 0.3996 0.3996
Echinococcus granulosus tyrosine kinase 0.0211 1 1
Echinococcus multilocularis SH2 domain containing protein 7 0.0132 0.3996 0.3996
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0211 1 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.0211 1 1
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0132 0.3996 0.3996
Toxoplasma gondii protein kinase domain-containing protein 0.0079 0 0.5
Entamoeba histolytica SH2 domain containing protein 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Schistosoma mansoni signal transduction protein lnk-related 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0132 0.3996 0.3996
Brugia malayi SH2 domain containing protein 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Brugia malayi Protein kinase domain containing protein 0.0211 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0211 1 1
Echinococcus multilocularis tyrosine kinase 0.0211 1 1
Onchocerca volvulus 0.0132 0.3996 0.3996
Echinococcus multilocularis NCK adaptor protein 0.0132 0.3996 0.3996
Echinococcus granulosus tyrosine protein kinase Fyn 0.0211 1 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0211 1 1
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0132 0.3996 0.3996
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0132 0.3996 0.3996
Brugia malayi SH2 domain containing protein 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Echinococcus multilocularis tyrosine protein kinase Blk 0.0211 1 1
Echinococcus multilocularis SH2 motif 0.0132 0.3996 0.3996
Echinococcus multilocularis 0.0132 0.3996 0.3996
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0079 0 0.5
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Onchocerca volvulus 0.0132 0.3996 0.3996
Echinococcus granulosus SH2 motif 0.0132 0.3996 0.3996
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Schistosoma mansoni GTPase activating protein 0.0132 0.3996 0.3996
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0211 1 1
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Echinococcus granulosus expressed conserved protein 0.0132 0.3996 0.3996
Loa Loa (eye worm) TK/FER protein kinase 0.0211 1 1
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0132 0.3996 0.3996
Onchocerca volvulus 0.0132 0.3996 0.3996
Onchocerca volvulus 0.0211 1 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0132 0.3996 0.3996
Loa Loa (eye worm) STAT protein 0.0132 0.3996 0.3996
Echinococcus multilocularis signal transduction protein lnk realted 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0079 0 0.5
Echinococcus multilocularis tensin 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0132 0.3996 0.3996
Brugia malayi protein-tyrosine kinase 0.0211 1 1
Schistosoma mansoni adapter molecule crk 0.0132 0.3996 0.3996
Trichomonas vaginalis TK family protein kinase 0.0079 0 0.5
Brugia malayi Protein kinase domain containing protein 0.0211 1 1
Echinococcus multilocularis c src tyrosine kinase 0.0211 1 1
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0132 0.3996 0.3996
Echinococcus multilocularis SH2 motif 0.0132 0.3996 0.3996
Echinococcus granulosus tyrosine kinase 0.0211 1 1
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Schistosoma mansoni tensin 0.0132 0.3996 0.3996
Loa Loa (eye worm) hypothetical protein 0.0132 0.3996 0.3996
Schistosoma mansoni nck2/grb4 0.0132 0.3996 0.3996
Brugia malayi hypothetical protein 0.0211 1 1
Brugia malayi Tensin 0.0132 0.3996 0.3996
Onchocerca volvulus 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0079 0 0.5
Onchocerca volvulus 0.0211 1 1
Brugia malayi SH2 domain containing protein 0.0132 0.3996 0.3996
Plasmodium falciparum protein kinase, putative 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Trypanosoma brucei Flagellum attachment zone protein 20 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Onchocerca volvulus 0.0211 1 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Onchocerca volvulus 0.0211 1 1
Echinococcus granulosus suppressor of cytokine signaling 7 0.0132 0.3996 0.3996
Toxoplasma gondii protein kinase 0.0079 0 0.5
Brugia malayi SH2 domain containing protein 0.0132 0.3996 0.3996
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0211 1 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0211 1 1
Trichomonas vaginalis STE family protein kinase 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0211 1 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0211 1 1
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0211 1 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0132 0.3996 0.3996
Giardia lamblia Kinase, NEK 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Echinococcus granulosus tyrosine protein kinase Blk 0.0211 1 1
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Brugia malayi STAT protein, DNA binding domain containing protein 0.0132 0.3996 0.3996
Brugia malayi Variant SH3 domain containing protein 0.0132 0.3996 0.3996
Schistosoma mansoni tyrosine kinase 0.0211 1 1
Entamoeba histolytica protein kinase, putative 0.0132 0.3996 0.3996
Schistosoma mansoni suppressor of cytokine signaling 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0211 1 1
Echinococcus granulosus N chimaerin 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Echinococcus granulosus NCK adaptor protein 0.0132 0.3996 0.3996
Loa Loa (eye worm) hypothetical protein 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0211 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0079 0 0.5
Loa Loa (eye worm) SH2 domain-containing protein 0.0132 0.3996 0.3996
Echinococcus granulosus tyrosine protein kinase Lyn 0.0211 1 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0132 0.3996 0.3996
Brugia malayi Variant SH3 domain containing protein 0.0132 0.3996 0.3996
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0132 0.3996 0.3996
Trichomonas vaginalis protein tyrosine kinase, putative 0.0079 0 0.5
Brugia malayi SH2 domain containing protein 0.0132 0.3996 0.3996
Brugia malayi Protein kinase domain containing protein 0.0211 1 1
Brugia malayi Sex muscle abnormal protein 5 0.0132 0.3996 0.3996
Plasmodium falciparum protein kinase, putative 0.0079 0 0.5
Giardia lamblia Protein 21.1 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Giardia lamblia Kinase 0.0079 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0079 0 0.5
Brugia malayi Protein kinase domain containing protein 0.0211 1 1
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0079 0 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0132 0.3996 0.3996
Trichomonas vaginalis conserved hypothetical protein 0.0079 0 0.5
Echinococcus granulosus SH2 domain containing protein 7 0.0132 0.3996 0.3996
Trichomonas vaginalis conserved hypothetical protein 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0132 0.3996 0.3996
Echinococcus granulosus growth factor receptor bound protein 2 0.0132 0.3996 0.3996
Schistosoma mansoni tyrosine kinase 0.0211 1 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.3996 0.3996
Echinococcus multilocularis N chimaerin 0.0132 0.3996 0.3996
Schistosoma mansoni tyrosine kinase 0.0211 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0211 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Schistosoma mansoni tyrosine kinase 0.0211 1 1
Echinococcus multilocularis SHC transforming protein 3 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0132 0.3996 0.3996
Plasmodium vivax tyrosine kinase-like protein, putative 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Echinococcus multilocularis SH2 motif 0.0132 0.3996 0.3996
Loa Loa (eye worm) TK/FER protein kinase 0.0211 1 1
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0132 0.3996 0.3996
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0211 1 1
Plasmodium falciparum protein kinase, putative 0.0079 0 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.0211 1 1
Echinococcus granulosus SHC transforming protein 3 0.0132 0.3996 0.3996
Trypanosoma cruzi protein kinase, putative 0.0079 0 0.5
Brugia malayi SH2 domain containing protein 0.0132 0.3996 0.3996
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0211 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0079 0 0.5
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0132 0.3996 0.3996
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0132 0.3996 0.3996
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0132 0.3996 0.3996
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0079 0 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0211 1 1
Echinococcus granulosus hypothetical protein 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Echinococcus granulosus tensin 0.0132 0.3996 0.3996
Trypanosoma brucei Pseudokinase, putative 0.0079 0 0.5
Brugia malayi RhoGAP domain containing protein 0.0132 0.3996 0.3996
Trypanosoma brucei protein kinase, putative 0.0079 0 0.5
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Brugia malayi hypothetical protein 0.0132 0.3996 0.3996
Brugia malayi SH2 domain containing protein 0.0211 1 1
Schistosoma mansoni growth factor receptor-bound protein 0.0132 0.3996 0.3996
Onchocerca volvulus 0.0211 1 1
Loa Loa (eye worm) SRC-1 0.0211 1 1
Brugia malayi cytokine inducible SH2-containing protein 5 0.0132 0.3996 0.3996
Brugia malayi tRNA modification GTPase TrmE family protein 0.0132 0.3996 0.3996
Echinococcus granulosus SH2 domain containing adapter protein F 0.0132 0.3996 0.3996
Trichomonas vaginalis AGC family protein kinase 0.0079 0 0.5
Schistosoma mansoni vav2 0.0132 0.3996 0.3996
Brugia malayi SRC-1 0.0211 1 1
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0132 0.3996 0.3996
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0211 1 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0211 1 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0132 0.3996 0.3996
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0079 0 0.5
Schistosoma mansoni tensin 0.0132 0.3996 0.3996
Loa Loa (eye worm) hypothetical protein 0.0132 0.3996 0.3996
Loa Loa (eye worm) TK protein kinase 0.0211 1 1
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Echinococcus multilocularis tensin 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Echinococcus granulosus suppressor of cytokine signaling 6 0.0132 0.3996 0.3996
Echinococcus granulosus tyrosine protein kinase Srms 0.0211 1 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0211 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0211 1 1
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Toxoplasma gondii STE kinase 0.0079 0 0.5
Schistosoma mansoni hypothetical protein 0.0132 0.3996 0.3996
Trichomonas vaginalis TKL family protein kinase 0.0079 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0211 1 1

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.016 ug ml-1 Tested for in vitro antifungal activity against Candida albicans SANK51486 ChEMBL. 12067542
MIC (functional) = 0.016 ug ml-1 Tested for in vitro antifungal activity against Candida albicans SANK51486 ChEMBL. 12067542
MIC (functional) = 0.031 ug ml-1 Tested for in vitro antifungal activity against Candida albicans ATCC24433 ChEMBL. 12067542
MIC (functional) = 0.031 ug ml-1 Tested for in vitro antifungal activity against Candida albicans TIMM3164 ChEMBL. 12067542
MIC (functional) = 0.031 ug ml-1 Tested for in vitro antifungal activity against Candida albicans ATCC64550 ChEMBL. 12067542
MIC (functional) = 0.031 ug ml-1 Tested for in vitro antifungal activity against Candida albicans ATCC24433 ChEMBL. 12067542
MIC (functional) = 0.031 ug ml-1 Tested for in vitro antifungal activity against Candida albicans TIMM3164 ChEMBL. 12067542
MIC (functional) = 0.031 ug ml-1 Tested for in vitro antifungal activity against Candida albicans ATCC64550 ChEMBL. 12067542
MIC (functional) = 0.125 ug ml-1 Tested for in vitro antifungal activity against Candida glabrata ATCC90030 ChEMBL. 12067542
MIC (functional) = 0.125 ug ml-1 Tested for in vitro antifungal activity against Cryptococcus neoformans TIMM1855 ChEMBL. 12067542
MIC (functional) = 0.125 ug ml-1 Tested for in vitro antifungal activity against Cryptococcus neoformans TIMM1855 ChEMBL. 12067542
MIC (functional) = 0.25 ug ml-1 Tested for in vitro antifungal activity against Candida tropicalis ATCC750 ChEMBL. 12067542
MIC (functional) = 0.5 ug ml-1 Tested for in vitro antifungal activity against Candida albicans ATCC24433 in the presence of horse serum (20%) ChEMBL. 12067542
MIC (functional) = 0.5 ug ml-1 Tested for in vitro antifungal activity against Candida albicans SANK51486 in the presence of horse serum (20%) ChEMBL. 12067542
MIC (functional) = 0.5 ug ml-1 Tested for in vitro antifungal activity against Candida albicans ATCC24433 in the presence of horse serum (20%) ChEMBL. 12067542
MIC (functional) = 0.5 ug ml-1 Tested for in vitro antifungal activity against Candida albicans SANK51486 in the presence of horse serum (20%) ChEMBL. 12067542
MIC (functional) = 16 ug ml-1 Tested for in vitro antifungal activity against Candida parapsilosis ATCC90018 ChEMBL. 12067542
MIC (functional) > 16 ug ml-1 Tested for in vitro antifungal activity against Aspergillus fumigatus ATCC26430 ChEMBL. 12067542

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.