Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | matrixin family protein | 0.140655 | 0.552936 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.211506 | 0.851931 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0134446 | 0.0160975 | 0.0188953 |
Onchocerca volvulus | Matrilysin homolog | 0.129023 | 0.503847 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.246592 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0581721 | 0.204851 | 0.330981 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0173657 | 0.0326445 | 0.5 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0708507 | 0.258356 | 0.433817 |
Schistosoma mansoni | hypothetical protein | 0.0824829 | 0.307445 | 0.964542 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0173657 | 0.0326445 | 0.0547809 |
Mycobacterium ulcerans | hydrolase | 0.0708507 | 0.258356 | 0.233328 |
Loa Loa (eye worm) | matrixin family protein | 0.129023 | 0.503847 | 0.905651 |
Plasmodium vivax | hypothetical protein, conserved | 0.0173657 | 0.0326445 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0173657 | 0.0326445 | 0.5 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0708507 | 0.258356 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0173657 | 0.0326445 | 0.0383182 |
Loa Loa (eye worm) | hypothetical protein | 0.0581721 | 0.204851 | 0.330981 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0850208 | 0.318155 | 1 |
Schistosoma mansoni | amine oxidase | 0.0173657 | 0.0326445 | 0.0547809 |
Plasmodium vivax | hypothetical protein, conserved | 0.0173657 | 0.0326445 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.211506 | 0.851931 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0173657 | 0.0326445 | 0.0547809 |
Leishmania major | UDP-galactopyranose mutase | 0.0173657 | 0.0326445 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0581721 | 0.204851 | 0.330981 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0581721 | 0.204851 | 0.330981 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0581721 | 0.204851 | 0.624894 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0173657 | 0.0326445 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.229227 | 0.926715 | 1 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0173657 | 0.0326445 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0581721 | 0.204851 | 0.330981 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0152641 | 0.0237758 | 0.0254199 |
Echinococcus multilocularis | 0.0173657 | 0.0326445 | 0.0383182 | |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0173657 | 0.0326445 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.246592 | 1 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0173657 | 0.0326445 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0581721 | 0.204851 | 0.330981 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0173657 | 0.0326445 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0581721 | 0.204851 | 0.330981 |
Loa Loa (eye worm) | hypothetical protein | 0.0708507 | 0.258356 | 0.433817 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.129023 | 0.503847 | 1 |
Onchocerca volvulus | 0.0581721 | 0.204851 | 0.365462 | |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0173657 | 0.0326445 | 0.5 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0173657 | 0.0326445 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.0824829 | 0.307445 | 0.528166 |
Onchocerca volvulus | Matrilysin homolog | 0.0581721 | 0.204851 | 0.365462 |
Brugia malayi | Matrixin family protein | 0.0581721 | 0.204851 | 0.330981 |
Brugia malayi | Matrixin family protein | 0.140655 | 0.552936 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0173657 | 0.0326445 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0173657 | 0.0326445 | 0.0547809 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0708507 | 0.258356 | 0.252453 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0134446 | 0.0160975 | 0.0188953 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0173657 | 0.0326445 | 0.0383182 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0173657 | 0.0326445 | 0.0383182 |
Onchocerca volvulus | 0.0824829 | 0.307445 | 0.583189 | |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0173657 | 0.0326445 | 0.0383182 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 6.81 uM | Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
EC50 (functional) | 6.811 uM | ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | ChEMBL. | 20485428 |
EC50 (functional) | = 15 uM | Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
EC50 (functional) | > 15 uM | ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | ChEMBL. | 20485428 |
IC50 (functional) | > 10.42 uM | DNDI | DNDI. | No reference |
Percent growth inhibition (functional) | = 75.7 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye | Saint Jude. | 20485428 |
Percent growth inhibition (functional) | = 81.2 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye | Saint Jude. | 20485428 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | |||
Plasmodium falciparum | ChEMBL23 | 20485428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.