Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0726 | 0.2879 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0726 | 0.2879 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0101 | 0.0248 | 0.0862 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0101 | 0.0248 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0726 | 0.2879 | 1 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0101 | 0.0248 | 1 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.2417 | 1 | 1 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.2417 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0042 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0042 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0042 | 0 | 0.5 |
Brugia malayi | P38 map kinase family protein 2 | 0.0101 | 0.0248 | 0.0862 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.2417 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0101 | 0.0248 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0101 | 0.0248 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0101 | 0.0248 | 0.0862 |
Brugia malayi | Stress-activated protein kinase jnk-1 | 0.0726 | 0.2879 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0101 | 0.0248 | 0.0862 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0101 | 0.0248 | 0.0862 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0101 | 0.0248 | 0.0862 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0042 | 0 | 0.5 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.0726 | 0.2879 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0101 | 0.0248 | 0.0862 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0101 | 0.0248 | 0.0862 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0042 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.