Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | jmjC domain containing protein | 0.0058 | 1 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0058 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.4632 | 0.4292 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0596 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.21 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.4632 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.4632 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.7893 | 0.7893 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.21 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0596 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.7893 | 0.776 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.21 | 0.16 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0596 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0058 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.21 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0596 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.21 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.7893 | 0.776 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0058 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.7893 | 0.7893 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.4632 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.21 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.4185 | 0.3817 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.4185 | 0.3817 |
Brugia malayi | hypothetical protein | 0.0025 | 0.21 | 0.21 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0596 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0058 | 1 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0058 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0596 | 0.0596 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.4632 | 0.4292 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.21 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.4632 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.4632 | 0.4292 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.4185 | 0.4185 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.21 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.4632 | 0.4632 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.21 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0596 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0058 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.4632 | 0.4292 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0596 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.